| 摘要: |
| ［目的］观察鼻咽癌（nasopharyngeal carcinoma, NPC）组织PI3K和caspase-3的表达，探讨其相互关系及其在鼻咽癌发生发展中的作用。［方法］应用免疫组织化学法检测60例鼻咽癌与23例鼻咽部慢性炎症组织PI3K和caspase-3的表达水平。［结果］NPC组中PI3K的阳性率分别为86.7%（52/60）与60.9%（14/23）（P<0.05）； caspase-3的表达率分别为 48.3%（29/60）与73.9%（17/23）（P<0.05）；NPC中，PI3K的表达强度与caspase-3的表达呈负相关（P<0.05）。［结论］PI3K/Akt/mTOR信号通路的激活可能通过某种机制抑制caspase-3的表达，进而减少肿瘤细胞的凋亡，这在鼻咽癌的发病中起一定的作用。 |
| 关键词: 鼻咽癌 PI3K caspase-3 |
| DOI：10.11724/jdmu.2007.02.09 |
| 分类号:R392.11 |
| 基金项目: |
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| Expression of PI3K and caspase-3 in nasopharyngeal carcinoma |
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CHEN Ying-jie,LIU Jian,TAO Ya-jun,JIA Xin-shan
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1.Department of Pathology, China Medical University, Shenyang 110001, China;2.Department of Pathology, Medical College of Dalian University, Dalian 116622, China
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| Abstract: |
| ［Objective］To investigate the effects of expressions of PI3K and caspase-3 on the tumorigenesis in nasopharyngeal carcinoma.［Methods］Immunohistochemical method was used to examine expressions of PI3K and caspase-3 in 60 nasopharyngeal carcinomas (group1) and 23 non-tumor nasopharyngeal tissues (group2). ［Results］In group 1 and group 2, the expression rates of PI3K were 86.7%(52/60) and 60.9%(14/23) respectively, (P<0.05); While the rates of caspase-3 were 48.3%(29/60) and 73.9%(17/23) respectively, (P<0.05). The expression of caspase-3 was negatively correlated with that of PI3K in nasopharyngeal carcinoma (P<0.05).［Conclusions］The activation of PI3K/Akt/mTOR signaling pathway may inhibit the expression of caspase-3 to decrease apoptosis and promote proliferation of NPC cells. |
| Key words: nasopharyngeal carcinoma, PI3K, caspase-3 |
