HPV感染对宫颈鳞癌组织Fas/FasL表达的影响

Effect of human papilloma virus on expression of Fas/Fasl in cervical carcinoma

关键词:  子宫颈癌  Fas  FasL  HPV  免疫组织化学

Key words:  carcinoma of cervix  Fas  Fas-ligand  human papilloma virus  immunohistochemistry

摘要:

［目的］探讨人乳头状瘤病毒（HPV) 感染对宫颈癌组织Fas /FasL（Fas配体）表达的影响。［方法］用免疫组化链霉菌抗生物素过氧化物酶（SP）法检测55例宫颈鳞癌和27例宫颈炎组织HPV 及Fas、FasL蛋白的表达。［结果］ 在宫颈鳞癌和宫颈炎组，HPV感染率分别为76.4%和85.2%（P>0.05），Fas表达阳性率分别为50.9%和 75.0%（P<0.05），FasL分别为72.7%和83.3%（P>0.05）。在宫颈癌HPV感染和未感染组，Fas表达阳性率分别为40.6%和61.9%（P<0.05）；FasL分别为76.2%和21.4%（P<0.05）。在宫颈炎HPV感染和未感染组，Fas表达阳性率分别为67.2%和96.7%（P<0.05）；FasL分别为75.0%和45.2%（P<0.05）。［结论］HPV感染可能会使宫颈癌细胞Fas基因表达下调，FasL表达上调，使癌细胞发生免疫逃避，从而促进宫颈癌的发生。

Abstract:

［Objective］To study the effect of human papilloma virus（HPV）on expressions of Fas/Fasl in carcinogenesis of cervical carcinoma.［Methods］The expressions of HPV and Fas/Fasl in 55 cervical carcinomas and 27cervicitis tissues were detected by SP method.［Results］In cervical carcinoma and cervicitis groups, the expression rates of HPV were 76.4% and 85.2% (P>0.05); the rates of fas were 50.9% and 75.0% (P<0.05), the rates of Fasl were 72.7% and 83.3% (P>0.05)respectively. In cervical carcinoma with HPV infection　and without, the expression rates of Fas were 40.6% and 61.9% (P<0.05),and the rates of FasL were 75.0% and 45.2%（P<0.05）respectively.［Conclusions］The inhibition of Fas expression,and up-regulation of Fasl expression　from HPV in cancer cells. Maybe promote development of cervical carcinoma.