宫颈癌hMSH2及PCNA的异常表达

Abnormal expression of hMSH2 and PCNA in cervical carcinoma

关键词:  宫颈癌  hMSH2  PCNA  免疫组织化学

Key words:  cervical carcinoma  hMSH2  PCNA  immunohistochemistry

摘要:

［目的］ 探讨错配修复蛋白（hMSH2）及增殖细胞核抗原PCNA异常表达在宫颈癌发病中的意义。［方法］免疫组织化学SP法检测67例宫颈癌和22例非癌子宫颈上皮组织hMSH2与PCNA的表达情况。［结果］ 宫颈癌组hMSH2阳性表达率为55.20%（37/67），高于非癌上皮组的27.30%（6/22）（P<0.05）；宫颈癌组PCNA阳性表达率为73.10%（49/67），高于非癌上皮组的59.10%（13/22），但差异不显著（P>0.05）。宫颈癌hMSH2表达阳性组的PCNA阳性表达率为83.30%（31/37），高于hMSH2表达阴性组的60.00%（12/30）（P<0.05）。［结论］ 错配修复蛋白（hMSH2）与增殖细胞核抗原PCNA相互影响共同参与宫颈癌的发生。

Abstract:

［Objective］To study the significance of abnormal expressions of DNA mismatch repair protein (hMSH2) and proliferating cell nuclear antigen (PCNA) in cervical carcinogenesis. ［Methods］ Immunohistochemistry SP method was used to detect the expressions of hMSH2 and PCNA in 67 cervical carcinomas and 22 cervical non-carcinoma eptheis. ［Results］ The positive expression rate of hMSH2 in cervical carcinoma group being 55.20% was higher than that in cervical non-carcinoma epithchiam group being 27.3% (P<0.05); the positive expression rates of PCNA in cervical carcinoma group and cervical non-carcinoma epithcham group were 73.10% and 59.10% (P>0.05); the positive expression rate of PCNA of cervical carcinoma with the hMSH2 expression being 83.30% was higher than that without the hMSH2 expression being 60.00% (P<0.05). ［Conclusion］ Interaction between mismatch repair protein (hMSH2) and proliferating cell nuclear antigen PCNA may contribute to carcinogenesis of cervical carcinoma.