消化系统恶性肿瘤患者血清TSGF检测的临床意义

Clinical significance of serum TSGF assay in digestive malignant tumor

关键词:  肿瘤标志物  肿瘤特异性生长因子（TSGF）  消化系统

Key words:  tumor marker  tumor specific grow factor (TSGF)  digestive system malignant tumor

摘要:

［目的］ 探讨肿瘤特异性生长因子（TSGF）在消化系统恶性肿瘤诊断上的价值及其临床意义。［方法］使用 TSGF检测试剂盒，用生化比色定量法测定血清中TSGF的含量。［结果］339例消化系统恶性肿瘤患者血清 TSGF的含量(71.03±11.24) u/mL显著高于正常对照组血清TSGF的含量(59.75±4.45) u/mL（P<0.01），阳性检出率达78.47%。另外，在42例进行化疗的患者中，15例有效者化疗后血清TSGF的含量(62.64±6.05) u/mL较化疗前(82.26±4.57) u/mL明显下降（P<0.01），6例化疗无效者化疗后血清 TSGF的含量(86.51±5.82) u/mL显著高于化疗前(65.76±5.92)u/mL（P<0.01）。［结论］ TSGF是一种新的、敏感性高的肿瘤标志物，对于消化系统恶性肿瘤的诊断、评价疗效和判断预后均有临床意义。

Abstract:

［Objective］ To evaluate the value of Tumor Specific Grow Factor (TSGF) in diagnosis of digestive malignant tumor and its clinical significance. ［Methods］ TSGF in serum and chromoparic material cause a chromoparic reserved by chromatography. The concentration of TSGF was got from the standard curve. The 130 normal persons was control group. ［Result］The level of serum TSGF of 339 digestive malignant tumor patients was (71.03±11.24) u/mL significantly higher than that of control group (59.75±4.45) u/mL（P<0.01）. The positiverate was 78.47%. Out of 42 patients received chemotherapy. The level of serum TSGF of 15 response patients was (62.64±6.05) u/mL significantly lower than that of pre-chemotherapy (82.26±4.57) u/mL (P<0.01) and that of 6 patients that failed to respond to chemotherapy was (86.51±5.82) u/mL higher than prechemotherapy (65.76±5.92) u/mL (P<0.01). ［Conclusion］ The serum TSGF is a sensitivity, specificity, accuracy and broad-spectrum new tumor marker. There are clinical significance for diagnosis of digestive malignant tumor and judgment of curative effect and prognosis.