茶多酚对麻醉大鼠血流动力学的影响

Effect of TP on anesthetized rat's hemodynamics

关键词:  茶多酚  心功能  血流动力学

Key words:  TP  cardiac function  hemodynamic

摘要:

［目的］观察茶多酚（tea polyphenols, TP）对麻醉大鼠血流动力学的影响。［方法］ 将麻醉大鼠随机分为4组:生理盐水组、低剂量组(TP 25 mg/kg)、中剂量组(TP 50 mg/kg)、高剂量组(TP 100 mg/kg)，用在体心脏法测定血流动力学参数LVSP、LVEDP、±dp/dtmax、CO、BP、HR。［结果］TP 25 mg/kg低剂量组静脉给药对麻醉大鼠的BP无明显影响，但可以显著提高麻醉大鼠的LVSP，±dp/dtmax，CO；TP 50、100 mg/kg中高剂量组静脉给药可明显降低麻醉大鼠BP，HR，LVSP，±dp/dtmax，CO。［结论］TP静脉给药在一定剂量范围内有降压作用，同时随着剂量的增加，心功能由强心转为抑制作用。

Abstract:

［Objective］ To study the effect of TP on anesthetized rat's hemodynamics. ［Methods］ All the anesthetized rats were divided into4 groups at random: NS group; TP 25，50，100 mg/kg. The experiment method of in situ heart of anesthetized rats was employed. The effect of TP on anesthetized rat's hemodynamics (LVSP，LVEDP，±dp/dtmax，CO，BP，HR) was observed. ［Results］ TP 25 mg/kg administered intravenously(iv) can significantly increase LVSP, ±dp/dtmax, CO in anesthetized rats, but there is no obviousl change BP.TP 50 mg/kg (iv)and TP 100 mg/kg(iv) can significantly reduce BP,HR,LVSP, ±dp/dtmax，CO. ［Conclusion］ TP(iv) can decrease BP in some dose extent and left cardiac function was inhibited significantly from cardiac effect by increasing dose.