米索前列醇舌下含服在人工流产的应用

Use of subligual misoprostol in artifical abortion

关键词:  米索前列醇  早孕  人工流产  舌下含服

Key words:  misoprostol  early pregnancy  artifical abortion  sublingual

摘要:

［目的］探讨舌下含服米索前列醇（米索）应用于早孕人工流产术前的可行性、安全性及有效性。［方法］将198例拟行人工流产的妇女随机分为口服米索组96例（A组）、舌下含服米索组102例（B组）。A组术前２ h口服米索前列醇400 μg，B组术前0.5 h舌下含服米索前列醇400 μg。观察并比较两组不良反应发生率、宫颈扩张效果、术中出血量、镇痛效果及人工流产综合征发生情况。［结果］B组不良反应发生率低于A组，差异有显著性（χ²＝9.62～23.8, P<0.01）；两组宫颈扩张效果、术中出血量、镇痛效果及人工流产综合征发生率均无显著性差异（P>0.05）。 ［结论］米索前列醇舌下含服可作为人工流产术前扩张宫颈的理想给药方法。

Abstract:

［Objective］To investigate the feasibility,safety,efficacy of sublingual misoprostol in artifical abortion. ［Methods］198 women undergoing termination of first-trimester pregnancy were randomly divided into two groups. Women in group A took 400 μg of misoprostol in 2 hours pre-operation、 group B sublingual 400μg of misoprostol in half-hours pre-operation.The side effects of misoprostol, dilatation of cervix、amount of bleeding during operation、painful degree and induced abortion syndrome were observed. ［Results］ The side effects in group B was fewer than in group A（χ²＝9.62～23.8, P<0.01）.There were no significant difference in dilatation of cervix、amount of bleeding during operation、painful degree and induced abortion syndrome between two groups（P>0.05）.［Conclusion］Sublingual misoprostol in half-hours pre-operation is an ideal approach for dilatation of cervix.