三维适形放射治疗肺癌脑转移疗效分析

Analysis of therapy effiency affecting 3-Dimentional Conformal radiotherapy after brain metastases from lung cancer

关键词:  三维适形立体定向放射治疗  脑转移  疗效

Key words:  3-Dimentional Conformal radiotherapy  brain metastes  effiency

摘要:

探讨三维适形对肺癌脑转移的有效治疗方法。［方法］将病理诊断明确的肺癌脑转移患者39例分成2组，三维适形放射治疗3D-(CRT)19例，三维适形放射治疗前加全脑放疗(WBRT+3D-CRT)20例,3D-CRT治疗单次靶区平均周边剂量3～8Gy，总剂量40～60 Gy; WBRT+3D-CRT组：3D-CRT治疗单次靶区平均周边剂量同前，但总剂量为16～32 Gy，在3D-CRT之前WBRT2～3Gy/次，总剂量30～40 Gy/3～4w。［结果］3D-CRT和WBRT+3D-CRT肿瘤局部控制率分别为84.3%和85%（P>0.05），中位生存期分别为11和12.5个月（P>0.05）。［结论］全脑放疗加三维适形放射治疗(WBRT+3D-CRT)和三维适形放射治疗(3D-CRT)在肿瘤局部控制率和生存期上无明显差别。

Abstract:

［Objective］To explore the effiencent methods after treatment of brain metastases from lung cancer with three dimentional radiotherapy.［Methods］Thirty-nine patients with brain metastes from lung cancer affirmed by pathology were divided into two groups:19 patients were received 3D-CRT and 20 patients were received 3D-CRT+WBRT,the patients of 3D-CRT groups received single target dose ranging from 3-8 Gy,with a total dose of 40-60 Gy;WBRT+3D-CRT:the total dose of whole brain radiotherapy (WBRT)was 30-40 Gy with 2-3 Gy per fraction，after that single target dose ranging from 3-8 Gy,with a total dose of 16-32 Gy.［Results］the local tumor control rates of 3D-CRT and WBRT+3D-CRT was84.3% and 85%（P>0.05）,the median suvival time was 11 and 12.5months（P>0.05）,［Conclusion］3D-CRT and WBRT+3D-CRT are the same in improving the local control rates and survival time.