| 摘要: |
| ［目的］ 探讨人类喉癌中YB-1蛋白表达的临床意义。［方法］ 应用免疫组织化学方法检测了89例人类喉癌标本中YB-1蛋白的表达情况。 ［结果］ 89例人类喉癌组织中YB-1蛋白阳性 率为56.2%。病理分期Ⅲ—Ⅳ期喉癌YB-1蛋白表达阳性率（76.0%）明显高于Ⅰ—Ⅱ期（48.4%）（P=0.0185）。YB-1蛋白表达与喉癌淋巴结转移密切相关（P=0.0022）。Kaplan-Meier生存曲线分析表明YB-1蛋白阳性者的术后生存率（65.5%）明显低于YB-1蛋 白阴性者（86.7%）（P=0.0045）。［结论］ 人类喉癌标本中YB-1蛋白的检测有利于对喉癌患者的诊断、局部淋巴结转移和预后情况作出客观判断。 |
| 关键词: YB-1蛋白 喉癌 预后 |
| DOI：10.11724/jdmu.2005.04.02 |
| 分类号:R739.6 |
| 基金项目: |
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| Clinical implication of YB-1 protein experession in laryngeal carcinomas |
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LI Jin-xiu1, GU Chun-dong1, Kimitoshi Kohno2
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1.Department of Otolaryngology, the First Affiliated Hospital of Dalian Medica l University, Dalian 116011, China;2.Department of Molecular Biology, Universi ty of Occupational and Environmental Health, School of Medicine, Kitakyushu 807- 8555, Japan
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| Abstract: |
| ［Objective］ To study the clinical significance of detection YB-1 protein expression in laryngeal carcinoma. ［Methods］ YB-1 prote in expression were detected in 99 laryngeal carcinoma samples with immunohistochemistry. ［Results］ The positive rate of YB-1 protein express ion in laryngeal carcinoma was 56.2%. The frequency of YB-1 protein expression in stage III-IV was significantly higher than that in stage I-II（P=0.0185）。YB-1 protein expr ession was associated with lymph node metastasis (P=0.0022). The patients with YB-1 positive expression had significantly shorter survival periods (65.5%) than those with YB-1 protein negative expression (86.7%) (P=0.0045, log-ran k test). ［Conclusion］ It suggested that the detection of human YB-1 protein ex pression in laryngeal carcinoma samples may be helpful in judging the diagnosis, lymph nodes metestasis and prognosis. |
| Key words: YB-1 protein laryngeal carcinoma prognosis |
