微创术联合应用三七皂甙类药物治疗中重度脑出血50例临床观察

Clinical observation of 50 patients of medium and severe cerebral hemorrhage who is treated by micro scar operation combined with sanchinoside drugs

关键词:  微创术  三七皂甙类药物-血塞通  中重度脑出血

Key words:  micro scar operation  sanchinoside drugs-Xuesaitong  medium and severe cerebral hemorrhage

摘要:

［目的］ 观察微创术（采用YL-1型一次性颅内血肿粉碎针）联合三七皂甙类药物治疗中重度脑出血的临床疗效。［方法］ 选取脑出血并经微创颅内血肿清除术的病人共100例，随机分为观察组和对照组各50例。观察组在微创术后应用三七皂甙类药物-血塞通注射液静点，2周为1疗程。对照组行微创术治疗。两组均行脑出血的常规治疗。分别计算术后第1天与第7天、第15天头颅CT上最大灶周脑水肿面积之差及神经功能缺损评分之差，将两组对应数值进行两两比较，从而观察患者脑水肿吸收的速度及神经功能缺损恢复的程度。［结果］两组病人术后第1天与第7天、第15天头颅CT上最大灶周水肿面积之差(即观察组1.08±0.16与1.86±0.24，对照组0.64±0.06与0.92±0.16)及神经功能缺损评分之差（即观察组6.16±2.24与8.34±2.52，对照组2.56±1.42与3.72±1.36）均有显著性差异（p＜0.01）。［结论］本方法不但能抢救病人的生命，而且通过病人脑水肿的尽快吸收，神经功能缺损亦得到了较快的康复。说明本方法治疗中重度脑出血具有显著的疗效。

Abstract:

［Objective］ Observe the clinical effect on patient of medium and severe cerebral hemorrhage who is treated by micro scar operation (with YL-1 abandon type intracranium hematoma smash needle) combined with sanchinoside drugs.［Method］ Select 100 patient with cerebral hemorrhage who is treated with micro scar intracranium hematoma clearance operation, divided into observation group(50 patients)and blank group(50 patients) randomly.Patients in observation group were treated by injection Xuesaitong , a anchinoside drug ,after the micro scar intracranium hematoma clearance operation.Patients in blank group were treated by micro scar intracranium hematoma clearance operation only. Both groups take routine treatment for cerebral hemorrhage.Calculate the largest difference of cerebral edema area around the hemorrhage focus on CT and the difference of grade point for dysfunction nerves on the 1st ,7th and 15th day after the operation .Observe the speed of cerebral edema absorption and the recovery of nerval function by taking a comparison between two groups.［Result］ There were significant differences on the largest difference of cerebral edema area around the hemorrhage focus on CT(namely: observation group 1.08±0.16 and 1.86±0.24，blank group 0.64±0.06and 0.92±0.16) and the difference of grade point for dysfunction nerves（namely: observation group 6.16±2.24 and 8.34±2.52， blank group 2.56±1.42 and 3.72±1.36） on the 1st and 7th , 15th day after the operation(p＜0.01). ［Conclusion］ This method can be used in salvage and can increase the speed of cerebral edema absorption and recovery of nerval function .It is a significant effect on the treatment of medium and severe cerebral hemorrhage.