| 摘要: |
| ［目的］探讨山莨菪碱(654-2)减轻静脉用红霉素副作用的临床可行性。［方法］随机选取需用红霉素治疗的儿科患者122例，分成观察组和对照组。观察组(61例)患者红霉素注射液混合654-2注射液静滴；对照组(61例)患者单纯静滴红霉素。比较两组红霉素副作用的发生率及被迫停药率。[结果]观察组静滴红霉素副作用作用发生率为42。6%，被迫停药率为8%。对照组副作用发生率为83.6%，被迫停药率为36.1%。差异具有显著性意义（Ｐ＜0.01）。［结论］山莨菪碱能有效减轻静滴红霉素的副作用，且具有安全性，值得儿科临床广泛应用。 |
| 关键词: 山莨菪碱 红霉素 副作用 |
| DOI：10.11724/jdmu.2005.02.25 |
| 分类号:R72 |
| 基金项目: |
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| Clinical observation on anisodamine (654-2) reducing side-effect of erythromycin intravenous injection |
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TAN Yang
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Department of Pediatrics, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027,China
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| Abstract: |
| ［Objective］To investigate the efficiency of 654-2 on reducting side effect of erythromycin in intravenous injection. ［Mehtods］ Of 122 children treated with erythromycin by IV drip were divided into two groups randomly. The observed groups (n=61) were given 654-2 intravenously. The controll groups (n=61) were used erythromycin only. ［Results］ The incidences of side-effect of two groups were 42.6% and 83.6% respectively. There were significant difference between the observed groups and the controll groups on reducing the side-effect of erythromycin (p<0.01). ［Conclusion］ 654-2 is safety and efficient to reduce side-reaction of of erythromycin in intravenous injection. |
| Key words: 654-2 erythromycin side-effect |
