| 摘要: |
| ［目的］探讨雌激素受体（ER）亚型及人乳头状瘤病毒（HPV）感染在不同程度宫颈病变中的相互作用及其对宫颈病变进展的影响。 ［方法］应用免疫组化方法检测ER α/β两种亚型及HPV16-L1/E7两种蛋白在66例不同程度宫颈病变组织中的表达。 ［结果］宫颈癌组的HPV16-L1(-)/HPV16-E7(+)者（42.9%）及ERβ阳性率（61.9%）高于非宫颈癌组（13.3%和33.3%），差异有显著性（P=0.019和P=0.029），并且HPV的表达状态与ERβ的表达相关。 ［结论］ERβ可能通过影响HPV在宿主细胞中的感染状态对宫颈病变的发展起一定影响。 |
| 关键词: 雌激素受体 人乳头状瘤病毒 宫颈病变 免疫组化 |
| DOI：10.11724/jdmu.2005.02.01 |
| 分类号:R711 |
| 基金项目: |
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| Study of ER and HPV in progression of cervical lesions |
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SHANG Yu-hong1, WEI Li-hui2, BAI Li-xia2, Bao Dong-mei3
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1.Department of Obstetrics and Gynecology, Fist Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2.Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China;3.Department of Pathology, Peking University People's Hospital, Beijing 100044, China
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| Abstract: |
| ［Objective］ To investigate the expression and interaction between the ER and HPV16 in cervical lesions. ［Methods］ The immunohistochemistry method was used to study the expression of α and β isoforms of ER and HPV16-L1/E7 in 66 cases including chronic inflammation, atypical hyperplasia and invasive cevical carcinoma. ［Results］ There were more ERβ positive cases （61.9%）and HPV16-L1(-)/HPV16-E7(+) cases （42.9%） in the carcinoma group than the non-carcinoma group （13.3% and 33.3%）（P=0.019 and P=0.029）, and the states of HPV expression is closely related to whether ERβpositive or not. ［Conclusions］ ERβ maybe affect the progression of cervical lesions by determining the infection state of HPV. |
| Key words: human papillomavirus estrogen receptor cervical lesion immunohistochemistry |
