原发性高血压并高尿酸血症与C反应蛋白关系探讨

Relationship between essential hypertension with elevated uric acid and levels of C-reactive protein

关键词:  原发性高血压  C反应蛋白  尿酸  炎症

Key words:  essential hypertension  C-reactive protein  uric acid  inflammation

摘要:

[目的 ]探讨原发性高血压并高尿酸血症与血清C反应蛋白 (CRP)浓度的关系。 [方法 ]对5 0名原发性高血压患者 (包括尿酸高与尿酸正常 )及 5 0名健康人检查 ,测CRP浓度与尿酸浓度及其他生化指标 ,比较血尿酸高、血尿酸正常及正常对照组血清CRP浓度的差异。 [结果 ]原发性高血压并高尿酸血症组CRP浓度 (6 .31± 2 .6 0 )mg/L及尿酸正常组高血压患者CRP浓度 (2 .80±1.95 )mg/L均高于正常对照组CRP浓度 (1.2 4± 1.2 6 )mg/L ,两者分别与正常对照组比较有显著性差异 (P <0 .0 1) ;原发性高血压并高尿酸血症组CRP浓度高于尿酸正常组高血压患者CRP浓度 ,两者比较有显著性差异 (P <0 .0 1)。 [结论 ]原发性高血压患者血清CRP浓度升高 ,且其血清尿酸浓度与CRP浓度呈正相关关系 (r =0 .6 2 2 ,P <0 .0 1)。

Abstract:

[Objective] To investigate the relationship between essential hypertension with elevated uric acid and levels of C-reactive protein (CRP). [Methods] By measured 50 essential hypertension patients and 50 healthy people with the level of CRP and the other biochemistry tests. Compared the relationship of CRP among essential hypertension with elevated uric acid, normal uric acid and healthy people. Results :The level of CRP(6.31±2.60)mg/L of essential hypertension patients with elevated uric acid and the level of CRP(2.80±1.95)mg/L of the normal uric ones are higher than that of the healthy people (1.24±1.26) mg/L, both of them have remarkable differences (P< 0.01 ); The level of CRP of essential hypertension patients with elevated uric acid is higher than the level of CRP of the normal uric acid ones, both of them have remarkable differences (P< 0.01); [Conclusions] Serum CRP level of essential hypertension patients is higher than that of healthy people, serum uric acid level is positive associated with CRP level (r=0.622,P<0.01).