| 摘要: |
| 非酒精性脂肪性肝炎(NASH)是非酒精性脂肪性肝病(NAFLD)的一种病理类型,可以进一步发展为肝纤维化、肝硬化等终末期病变.NASH发病与胰岛素抵抗、氧应激、细胞因子作用、遗传因素等多种因素有关.椐文献报道饮食控制,应用降脂、保肝药物及胰岛素增敏剂,改善内毒素血症,调节细胞因子水平等可能对NASH防治有一定作用. |
| 关键词: 非酒精性脂肪性肝病 胰岛素抵抗 药物治疗 |
| DOI：10.11724/jdmu.2004.01.23 |
| 分类号:R575.1 |
| 基金项目: |
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| Pathogenesis and therapy progress of nonalcoholic steatohepatitis |
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DENG Bin, DAI Lin
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Gastroenterology Department of 210 Hospital,Dalian 116021,China）
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| Abstract: |
| Nonalcoholic steatohepatitis （NASH）is a pathological type of nonalcoholic fatty liver disease（NAFLD）. NASH can progress to hepatic fibrosisor and cirrhosis. Pathogenesis of NASH is in association with insulin resistance, oxygen stress, disordered cytokine production, genetic factor and other factors. Diet, treatment of hyperlipidaemia and insulin resistance, improvement of endotoxemia, and adjustment of cytokine level may be beneficial to preven NASH. |
| Key words: nonalcoholic fatty liver disease insulin resistance medication |