冠心病患者超敏C反应蛋白的变化及临床意义

Clinical significance of sensitive C-reactive protein in patients with coronary heart disease

关键词:  C反应蛋白(SCRP)  冠心病  心绞痛  心肌梗死

Key words:  C-reactive protein  coronary heart disease angina  myocardial infraction

摘要:

探讨超敏C反应蛋白（SCRP）与冠心病（CHD）的关系。验证用SCRP评价冠心病的可行性。［方法］用BN-100测定42例冠脉造影证实的CHD患者。30例正常对照者及31例病例对照者的血清SCRP水平。CHD患者又分为心肌梗死组（AMI，13人），不稳定心绞痛组（UAP，12人），稳定心绞痛组（SAP，17人）。分析治疗前后SCRP水平的差异。［结果］CHD患者的血清SCRP水平（4.4±0.55）较正常对照组（2.9±0.50）显著增高（P<0.05）； AMI组（4.7±0.28）和UAP组（4.6±0.41）的SCRP水平明显高于SAP组（3.9±0.35）（P<0.01），但AMI组与UAP组的SCRP水平无显著性差异（P<0.05）。CHD各组的SCRP水平在治疗前后亦有显著性差异（P<0.01）。［结论］ SCRP水平的增高与CHD的发生和发展显著相关，SCRP可作为诊断CHD与评价冠心病严重程度的一个参考指标，值得临床推广。

Abstract:

To explore the association of sensitive C-reactive protein (SCRP) with coronary heart disease (CHD) and evaluate the feasibility. ［Method］ SCRP concentrations of 42 CHD patients including 13 cases of acute mycocardial infraction (AMI groupe) ,12 cases of unstable angina pectoris (UAP group) and 17 cases of stable angina pectoris (SAP group), another 31 patients without CHD served for compare and 30 normal subjects were examined by BN-100, later the articla analyse this variation of SCRP before and after treating.［Result］ SCRP concentration of CHD patients (4.4±0.05)was significantly higher than that of the normal subjects（2.9±0.50）（P＜0.05.The levels of SCRP of AMI(4.7±0.28) and UAP(4.6±0.41) group were higher than those in SAP group(3.9±0.35) (P<0.01). But there was no significant difference in the levels of SCRP between UAP group and AMI group (P＞0.05). ［Conclusion］ The elevation of SCRP has association with coronary heart disease. SCRP concentration may be used as an index for the evaluation of the severity of coronary heart disease.