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| 痹症停合剂对急性炎症的作用及其机制研究 |
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张厚利1, 齐艳1, 杨彤1, 黄福如2
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1.大连医科大学,药学院,辽宁,大连,116027;2.大连医科大学,第二临床学院,辽宁,大连,116027
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| 摘要: |
| 研究痹症停合剂对急性炎症的作用及其机制。［方法］ 采用小鼠耳二甲苯致炎模型和角叉菜胶诱发大鼠足肿胀模型观察痹症停合剂对急性炎症的作用，采用紫外分光光度法测定PGE的含量。［结果］ 痹症停合剂（5.63、2.82 g/kg,ig）可明显抑制二甲苯致小鼠耳炎性水肿，痹症停合剂（70.4、34.2、17.6 g/kg,ig）对大鼠角叉菜胶性足肿胀有明显抑制作用，痹症停合剂（70.4 g/kg,ig）明显降低大鼠角叉菜胶性足跖炎症组织内PGE含量。［结论］痹症停合剂对急性炎症具有明显抑制作用，其作用机制可能与其抑制PGE合成有关 |
| 关键词: 痹症停合剂 抗炎作用 PGE |
| DOI：10.11724/jdmu.2003.04.03 |
| 分类号:R96 |
| 基金项目: |
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| Studies of anti-inflammatory effect of Bizhengting and mechanism |
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ZHANG Hou-li1, QI Yan1, YANG Tong1, HUANG Fu-ru2
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1.College of Pharmacy, Dalian Medical University, Dalian 116027,China;2.The Second Affiliated Hospital of Dalian Medical University，Dalian 116027,China)
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| Abstract: |
| To study the anti-inflammatory effects and mechanism of Bizhengting(BZT).［Methods］ The anti-inflammatory action was observed by the xylene induced ear swelling and carrageenin-induced rat paw edema models. PGE level in rat inflammatory tissues was determined by UV-spect rophotography. ［Results］ The experiments proved that BZT(5.63,2.82 g·kg-1·d-1,ig) suppressed the swelling of mouse ear induced by xylene. BZT(70 .4，35.2,17.6 g·kg-1·d-1,ig) could inhibited carrageenin-induced rat paw edema. BZT decreased the contents of PGE in inflammatory tissue of rat p aw induced by carrageenan.［Conclusion］ BZT shows obviously diminished acute inflammation in animal models. |
| Key words: Bizhengting(BZT) anti-inflammatory effects PGE |