引用本文:孙秀华,马殿胜,戴朝霞,蒋葵,牟丽,李满林,戚春环.紫素联合顺铂化疗对晚期乳腺癌患者免疫功能的影响[J].大连医科大学学报,2003,25(2):.
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紫素联合顺铂化疗对晚期乳腺癌患者免疫功能的影响
孙秀华1, 马殿胜2, 戴朝霞1, 蒋葵1, 牟丽1, 李满林1, 戚春环1
1.大连医科大学,第二临床学院,辽宁,大连,116027;2.东港市中心医院,辽宁,丹东,118306
摘要:
[目的]观察紫素联合顺铂化疗对晚期乳腺癌患者免疫功能的影响.[方法]对11例晚期乳腺癌患者用紫素联合顺铂化疗,化疗前后用流式细胞仪测量CD4/CD8及NK细胞活性.[结果]化疗后CD4/CD8较化疗前无明显变化(P>0.05),NK细胞活性较化疗前升高(P<0.05).[结论]紫素联合顺铂化疗能提高晚期乳腺癌患者的免疫功能.
关键词:  紫素  顺铂  免疫功能
DOI:10.11724/jdmu.2003.02.11
分类号:R737.9
基金项目:
Effect on immune function in advanced breast cancer treated with paclitaxel and cisplation
SUN Xiu-hua,MA Dian-sheng,DAI Zhao-xia,JIANG Kui,MU Li,LI Man-lin,QI Chun-huan
The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Chi
Abstract:
To observe the effect of paclitaxel and cisplation on immune function in advanced breast cancer.[Methods]11 advanced breast cancer treated with paclitaxel and cisplation,CD4/CD8 and NK were measured using flow cytometry in 11 advanced breast cancer before and after chemotherapy. [Results] No evident case of changes of CD4/CD8 were observed after chemotherapy (P>0.05); NK was higher in post-treatment patients than in pre- treatment patients(P<0.05)。[Conclusion]Chemotherapy combining paclitaxel with cisplation for advanced breast cancer can activate patients' immune function.
Key words:  advanced breast cancer  paclitaxel  cisplation  immune function