| 摘要: |
| 探讨HPV-16、HSV-2、EBV感染及增殖细胞核抗原表达与宫颈癌的关系。［方法］采用免疫组化SP法分别检测54例宫颈癌和20例正常宫颈的HPV-16、HSV-2、EBV蛋白及PCNA表达情况。［结果］ HPV-16、HSV-2、EBV蛋白在宫颈癌组织和正常宫颈表达率分别为57.4%、38.9%、55.6%和5%、5%、10%（P<0.05）；PCNA在宫颈癌和正常宫颈表达率为81.5%和15%（P<0.05），而且随着宫颈癌病理分级的增高，其表达的阳性率也增高，强度增强；HPV-16阳性组的PCNA表达高于阴性组（P<0.05），HSV-2、EBV阳性组和阴性组的PCNA表达无显著差异（P>0.05）；3种病毒混合感染者的PCNA表达均为阳性。［结论］ HPV-16、HSV-2、EBV感染会促进宫颈癌的发生 |
| 关键词: 人乳头瘤病毒 单纯疱疹病毒 EB病毒 增殖细胞核抗原 宫颈癌 |
| DOI：10.11724/jdmu.2003.02.02 |
| 分类号:R73-3 |
| 基金项目: |
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| Relationship between infection of HPV-16, HSV-2,EBV,PCNA expression and cervical carcinoma |
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LIU Jian1, GUO Yi2, ZHANG Yan-kai3, WANG Zhao-hui4, LIU Min4, Lv Peng4, Lv Shen4
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1.Department of Pathology, Dalian University Medical College, Dalian 116622, China;2.Dalian Hospital of Gynecology and Obstetrics, Dalian 116023, China;3.Department of Gynecology and Obstetrics, the Second Clinic College, Dalian Medical University, Dalian 116027, China;4.Center of Laboratory,the Second Clinic College, Dalian Medical University, Dalian 116027, China)
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| Abstract: |
| To observe the relationship between infection of HPV-16, HSV-2 , EBV , PCNA expression and cervical carcinoma . ［Methods］ The expression of HPV-16, HSV-2 , EBV and PCNA in 54 cervical carcinoma tissues and 20 cervical normal tissues were examined by immunohistchemistry technique.［Results］ The expression of HPV-16、HSV-2、EBV in cervical carcinoma tissues and cervical normal tissues were 57.4%, 38.9%and55.6%; 5%, 5% and 10%（P<0.05）; the expression of PCNA in cervical carcinomas and normal tissues were 81.5%和15%（P<0.05）.With the increase of pathology grading, the positive rate increased. The expression of PCNA in HPV-16 positive group was higher than that in HPV-16 negative group. The difference of PCNA expression between HSV , EBV positive group and HSV , EBV negative group was not significant. The expression of PCNA in the cases of 3 viruses in fection were positive. ［Conclusion］ Infection of HPV-16、HSV-2、EBV promoted the occurrence of the cervical carcinoma. |
| Key words: HPV-16 HSV-2 EBV PCNA cervical carcinoma |