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| 甘草水提液抗实验性心律失常的作用 |
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黄彩云1, 谢世荣1, 杨静娴2, 黄胜英1, 高广猷2
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1.大连大学医学院,药理学教研室,辽宁,大连,116622;2.大连医科大学,药理学教研室,,辽宁,大连,116027
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| 摘要: |
| 观察甘草水提液的抗心律失常作用。［方法］制备大鼠和小鼠心律失常模型, i.v受试药物和对照药物，观察药物对心律失常的影响。［结果］甘草水提液(Water Extract Liquid of Glycyrrhiza Uralensis, WELG) 4 g·kg-1 （按生药计算） 能明显对抗乌头碱20 μg·kg-1和BaCl2 2 mg·kg-1 i.v 以及结扎左冠状动脉前降支诱发的大鼠室性心律失常 。甘草水提液也能明显对抗CaCl2-Ach (CaCl2 0.6% + Ach 0.0025%) 混合液10 mL/kg i.v诱发小鼠心房纤颤或扑动。大鼠心电图试验证明甘草水提液有负性频率作用，负性传导作用。这些作用可能是甘草水提液抗心律失常作用的药理学基础。［结论］甘草水提液对大鼠有明显的抗心律失常作用 |
| 关键词: 甘草水提液 奎尼丁 乌头碱 氯化钡 心律失常 |
| DOI：10.11724/jdmu.2003.01.05 |
| 分类号:R96 R972.2 |
| 基金项目: |
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| Antiarrhythmic effect of Water Extract liquid of Glycyrrhiza Uralensis |
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HUANG Cai-yun1, XIE Shi-rong1, YANG Jing-xian2, HUANG Sheng-ying1, GAO Guang-you2
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1..Depatment of Pharmacology, Medicine of Dalian Univesity, Dalian 116622;2.Depatment of Pharmacology, Dalian Medical University, Dalian 116027， China
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| Abstract: |
| To observe the antiarrhythmic effects of Water Extract Liquid of Glycyrrhiza Uralensis. ［Methods］ Arrhythmia were induced by aconitine, BaCl2, CaCl2-Ach and coronary ligation. The drug being tested and quinidine as control were administered in travenously to investigate the antiarrhythmic effects of the drugs. ［Results］ Water Extract Liquid of Glycyrrhiza Uralensis(WELG) 4 mg·kg-1 could inhibit markedly the ventricular arrhythmias induced by aconitine 20 μg·kg-1 or BaCl2 2 mg·kg-1 or coronary ligation in rat. It also obviously reduced the incidence of atrium fibrillation produced by CaCl2-Ach (CaCl2 0.6% + Ach0.0025%) 10mL/kg in mice. These actions were similar to Quinidine. The ECG of rats was significantly P-R chan-ged after i.v of WELG 4g·kg-1. WELG slows the heart rate and prolongs the P-R and Q-T intervals. ［Conclusion］ Water Raise Liquid of Glycyrrhetic has obvious antiarrhythmic effect in rats. |
| Key words: Water Extract Liquid of Glycyrrhiza Uralensis(WELG) quinidine aconitine barium chloride arrhythmias |