| 摘要: |
| [目的] 探讨粘附分子CD18、CD54粘附功能及其表达变化与急性脑梗塞(ICA)关系. [方法] 用流式细胞术检测88例ICA患者白细胞粘附分子CD18、CD54质量分数与脑梗塞治疗前后表达,并与30例正常人作对照. [结果] ICA患者CD18、CD54表达明显增高,与正常对照组比较差异显著(P<0.05),治疗前后比较CD18有显著性差异(P<0.05). [结论] CD18、CD54参与脑梗塞发生发展病理过程,CD18可作为诊断脑梗塞的一项辅助指标. |
| 关键词: 细胞粘附因子 CD18 CD54 脑梗塞 |
| DOI：10.11724/jdmu.2002.04.15 |
| 分类号:R743 |
| 基金项目: |
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| Research on expression of cell adhesion molecules CD18,CD54 in patients with acute cerebral infarction(ICA) |
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LUAN Gui-hong1, XU Wei-jia2, LIU Yu-ying1
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1.Dalian Central Hospital, Dalian 116033, China;2.Dalian Central of Clinical Laboratory, Dalian 116033, China
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| Abstract: |
| To explore the relation of adhesion function and change of expression of cell adhesion molecules CD18，CD54 with acute cerebral infarction (ICA). ［Methods］ In flow cell method (FCM), to detect expression of leukocyte adhesion molecules CD18，CD54 in 88 acute cerebral infarction patients with 30 controls, before and after treatment. ［Results］ The expression of CD18，CD54 was significantly raise, obviously different than the controls (P>0.05). ［Conclusion］CD18，CD54 might take part in occurrence of ICA pathology process. CD18，CD54 might take part in occurrence of ICA pathology process. CD18 is a additional diagnosis index for ICA. |
| Key words: cell adhesion molecules CD18 CD54 cerebral infarction |