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引用本文:	张宁,费淑香,范青,李玉竹,芮丽.尼莫地平固体分散片溶出度比较[J].大连医科大学学报,2001,23(4):.

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尼莫地平固体分散片溶出度比较
张宁¹, 费淑香¹, 范青¹, 李玉竹², 芮丽³
1.大连医科大学第二临床学院药剂科,;2.大连医科大学临床药学系95级,;3.澳利达药业股份有限公司,

摘要:

以进口尼莫地平薄膜包衣片为参考,比较国内两厂家的尼莫地平固体分散片溶出度.以乙醇:水(15:85)为溶出介质,在(37±0.5)℃下,浆法,进行溶出实验,采用紫外分光光度法测定并计算结果.各厂家尼莫地平片30 min内溶出度不低于70%.经t检验,3种样品组间45 min溶出度无显著性差异(P>0.05).

关键词: 尼莫地平固体分散片:溶出度

DOI：10.11724/jdmu.2001.04.16

分类号:R97

基金项目:

Dissolution of nimodipine solid dispersion tablets

ZHANG Ning¹, FEI Shu-xiang¹, FAN Qing¹, LI Yu-zhu², RUI Li³

1.Department of Pharmacy, the Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China;2.Department of Clinical Pharmic 95 Grade;3.Aolida Pharmaceutical CO., LTD, Harbin 150001)

Abstract:

To comparatively study dissolution of two kinds of nimodipine solid dispersion tablets with domestic tablets. The dissolution was measured in alcohol: water(15:85)as medium, according to the second method described in Chinese Pharmacopoeia (1995) appendix XC, and the temperature (37±0.5)℃.The content was measured by UV spectrophometry at 240 nm. The dissolution in 30 minutes was more than 70%, and there were no significant differences in dissolution parameters among their products(P＞0.05).

Key words: Nimodipine solid dispersion tablets dissolution