| 摘要: |
| 观察氧化苦参碱的抗心律失常作用。方法：制备大鼠心律失常模型。结果：氧化苦参碱（Oxymatrine, OM）10mg/kg, 20mg/kg能明显对抗乌头碱20μg/kg,Bacl 22mg/kg和结扎左冠状动脉前降支诱发的大鼠室性心律失常。 OM也能明显对抗Cacl2-Ach(Cacl2 0.6% + Ach 0.0025%)混合液10mg/kg诱发小鼠心房纤颤或扑动。大鼠心电图试验证明OM有负性频率作用，负性传导作用。这些作用可能是OM抗心律失常作用的药理学基础。结论：氧化苦参碱对大鼠有明显的抗心律失常作用。 |
| 关键词: 氧化苦参碱 奎尼丁 乌头碱 氯化钡 心律失常 |
| DOI：10.11724/jdmu.2001.04.08 |
| 分类号:R541.7 |
| 基金项目: |
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| Experimental studies on antiarrhythmic effects of oxymatrine |
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HUANG Cai-yun1, HUANG Sheng-ying1, XIE Shi-rong1, GAO Guang-you2
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1.Department Pharmacology Medicine of Dalian Univesity, Dalian 116622 China;2.Department of Pharmacology,Dalian Medical University,Dalian 116027 China)
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| Abstract: |
| To observe the antiarrhythmic effects of oxymatrine. Methods: to mave use of arrhythmic rat model. Results: oxymatrine(OM) 10mg/kg and 20μg/kg could inhibit markedly the ventricular arrhythmias induced by aconitine 20μg/kg or BaCl2 2 mg/kg or coronary ligation in rat. It also obviously reduced the incidence of atrium fibrillation produced by CaCl2-Ach (CaCl2 0.6% + Ach0.0025%) 10mg/kg in mice. These actions were similar to Quinidine. The ECG of rats Was significantly P-R chan-ged after i.v of OM 10 mg/kg. OM slows the heart rate and prolongs the P-R and Q-T intervals. Conclusion: oxymatrine has obvious ontiarrhythmic effect in rats. |
| Key words: oxymatrine (OM ) quinidine aconitine barium chloriae arrhythmias |