胃癌病人血清中血管内皮生长因子浓度的临床意义

Clinical significance of serum concentration of vascular endothelial growth factor in patients with gastric cancer

关键词:  胃肿瘤  血管内皮生长因子  肿瘤转移  血清

Key words:  stomach neoplasms  vascular endothelial growth factor(VEGF)  meoplasm metastasis  serum

摘要:

检测胃癌病人术前血清中血管内皮生长因子(VEGF)浓度，探讨其临床及病理意义。方法：应用酶联免疫技术(ELISA法)检测51例胃癌病人、9例慢性胃炎病人及10例健康人血清中VEGF浓度。结果：胃癌病人血清VEGF浓度高于慢性胃炎病人及健康对照组(P＜0.05)，慢性胃炎病人与健康对照组血清VEGF浓度无显著性差异(P＜0.05)。血清VEGF浓度与胃癌浸润深度(P＜0.05)、淋巴结转移(P＜0.01)、远处转移(P＜0.01)、肿瘤分期(P＜0.05)及肿瘤组织学分型(P＜0.05)、生长方式(P＜0.05)密切相关，与性别无关(P＜0.05)。结论：血清VEGF浓度与胃癌侵袭和转移密切相关。术前检测血清VEGF浓度可预测胃癌进展程度及侵袭和转移情况。

Abstract:

In this study,serum concentration of vascular endothelial growth factor (VEGF) was measured to detect its clinical significance in patients with gastric cancer, Methods; Enzyme linked immunosorbent assay(ELISA)were used to detect serum VEGF concentration in 51 cases of human gastric carcinoma,9 cases of chronic gastritis and 10 healthy controls. Results:Serum VEGF concentration was much higher(P＜0.05)in gastric cancer patients than that of chronic gastritis and healtby controls,But compared with healthy controls,serum VEGF concentration in chronic gastritis was not higher(P＜0.05). SerumVEGF concentration in gastric cancer patients were positively correlated with depth of invasion(P＜0.05), lymph node metastasis (P＜0.01), distant metastasis(P＜0.01), tumor stage(P＜0.05), histolohical type of tumor (P＜0.05) and growth style of tumor (P＜0.05), but no significant correletion with sex(P＜0.05). Conclusion:Serum VEGF concentration is closely correlated with invasion and metastasis in gastric carcinoma.