过期妊娠靶组织雌、孕激素受体水平测定

Estimation of estrogen receptor(ER)and progestin receptor(PR) contents in target tissues (placenta etc) of prolonged pregmancy

关键词:  过期妊娠  雌激素受体  孕激素受体  靶组织

Key words:  prolonged pregnancy  estrogen receptor  progestin receptor  target tissue

摘要:

探讨靶组织内(胎盘、胎膜、子宫下段)雌激素受体(ER)、孕激素受体(PR)的含量变化和过期妊娠的关系。方法：对过期妊娠(41，3/7～42，2/7周)择期剖宫产10例(实验组)，并与足月妊娠(38～40周，宫颈评分7分以上)择期剖宫产10例相对照(对照组)。分别在术中取胎盘、胎膜、子宫下段组织，采用免疫组化法检测ER、PR含量。结果：①过期妊娠胎盘内ER含量低于对照组，差异显著，χ2＝6.67(P<0.01)。而胎膜、子宫下段内ER值与对照组比较，无显著差异，P均>0.05。②两组各部位靶组织PR含量与对照组比较，均无显著差异，P>0.05。③两组靶组织ER/PR值比较，过期妊娠组胎盘、胎膜ER/PR值均低于对照组，差异显著，t＝2.38，P<0.05；t＝2.26，P<0.05，而子宫下段ER/PR值与对照组比较无显著差异，P>0.05。结论：胎盘、胎膜ER、PR含量变化和过期妊娠发生有关，尤其是胎盘内ER水平降低和过期妊娠关系密切。而子宫下段内ER、PR含量对过期妊娠似乎无影响

Abstract:

In order to investigate the relationship of ER and PR content changes in target tissues (placenta,fetal membrane and lower part of uterus)and prolonged pregnancy,ER and PR contents of placenta,fetal membrane and lower part of uterus in 10 prolonged pregnancy women were measured by immunohistochemical method and 10 full-term pregnancy women as control. ER content in placenta of prolonged pregnancy is lower than control group(χ2=6.67,P<0.01). However, comparing with control group, ER content in fetal membrane and lower part of uterus of prolonged pregnancy has no significant difference. PR content in two groups has no significant difference. The ER/PR in placenta and fetal membrane of prolonged pregnancy are lower than control(t=2.38, P<0.05; t=2.26, P<0.05). The result shows that ER and PR content changes in placenta and fetal membrane are associated with prolonged pregnancy.Especially lowered ER content in placenta is closely related to prolonged pregnancy.