| 摘要: |
| 目的:研究P16基因缺失与妇科肿瘤发生及恶性变的关系.方法:采用聚合酶链式反应技术(PCR),扩增16例妇科肿瘤组织中的P16基因.结果:16例妇科肿瘤组织中,有12例为恶性肿瘤,其中有4例出现P16基因缺失,缺失率为33.3%;有4例为良性肿瘤.未见P16基因缺失.结论:P16基因缺失可能与妇科肿瘤的发生及恶性变有关. |
| 关键词: 妇科瘤 P16基因 基因缺失 聚合酶链反应 |
| DOI：10.11724/jdmu.2000.01.17 |
| 分类号:R737.3 |
| 基金项目: |
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| Deletion of P16 gene in 16 gynaecological tmnors |
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Zhao Chunyan,Zhang Yaozheng,Sun Jin
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Department of Laboratory,Dalian Medical University,Dalian,China
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| Abstract: |
| Objective:To investigate the possible relationship between deletion of P16 gene and abiogenesis of gynaecological tumor.Methods:16 gynaecologial tumor tissue were amplified for P16 gene by polymerase chain reaction-based analysis.Result:Of 12 gynaecological specimens, 4(33.3%)showed homozygous deletion of P16 gene.No deletion was detected in 4 malignant tumor. Conclusions:Deletion of P16 gene might contribute to the abiogenesis and aggraration of gynaecological tumor. |
| Key words: gynaecological tumor P16 gene gene deletion polymerase chain reaction |