| 摘要: |
| 子宫内膜异位症（endometriosis，EM），简称内异症，是育龄期女性的常见疾病，其患者不孕率高达40%，且易复发，给患者身心健康带来巨大的影响。但是内异症的病因尚不确切，其引起的不孕更是多因素相互作用的结果。卵巢储备功能下降、盆腔解剖结构改变、内分泌因素等都可能是内异症诱发不孕的作用因素，而免疫环境改变也与内异症性不孕有着密切联系。本文从内异症的免疫学变化、免疫细胞与内异症性不孕的关系、内异症性不孕相关的细胞因子3个方面综述内异症引起不孕的免疫学因素，探讨其发病机制及潜在治疗方案。 |
| 关键词: 子宫内膜异位症 不孕 免疫细胞 细胞因子 |
| DOI： |
| 分类号:R711.71 |
| 基金项目:国家人类遗传资源共享服务平台苏州创新中心专项（YCZYPT[2020]06-2） |
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| Advances in immunology on infertility associated with endometriosis |
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WANG Yingyao1, CHEN Youguo2
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1.Department of Gynecology, Kunshan Maternity and Children's Health Care Hospital, Suzhou 215300,China;2.Department of Obstetrics and Gynecology, the First Affiliated Hospital of Soochow University, Suzhou215000, China
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| Abstract: |
| Endometriosis (EM), is a common disease among women in childbearing age. Endometriosis is prone to high recurrence and infertility, which seriously affect the physical and mental health of patients. However, the etiology of endometriosis is still uncertain, and the infertility associated with endometriosis is the result of the interaction of many factors. Ovarian reserve, pelvic anatomy and endocrine factors may be the factors of EM-induced infertility. Changes of immune environment are also closely related to infertility associated with endometriosis. In this manuscript, the immunological changes of endometriosis, the relationship between immune cells and endometriosis infertility, and the cytokines related to endometriosis infertility were reviewed in order to provide new ideas for the treatment of endometriosis. |
| Key words: endometriosis infertility immune cell cytokines |
