| 摘要: |
| 癫痫是一种常见的大脑疾病，其发病机制复杂多样，至今尚未完全明确。但随着电生理学技术的发展，越来越多的研究结果揭示了癫痫与离子通道的联系。离子通道是神经系统兴奋性产生与调节的关键因子，Nav1.6作为电压门控钠通道（VGSCs）的亚型之一，其介导的持续性Na+电流（INaP）和复活性Na+电流（INaR）是神经元兴奋性的重要组成。Nav1.6通道表达量的改变及基因突变引起的功能异常均在癫痫中发挥重要作用，可见NaV1.6通道功能障碍是癫痫发病机制之一。通过对该通道的进一步研究有助于了解癫痫的发病机制，并找到有效的治疗方法。 |
| 关键词: 癫痫 发病机制 NaV1. |
| DOI： |
| 分类号:R741 |
| 基金项目: |
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| Research progress of NaV1.6 channel in the pathogenesis of epilepsy |
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YANG Junting1, WANG Yuheng1, GUO Huishu2, CAI Zhengxu1
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1.Department of Neurology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2.Central Laboratory, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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| Abstract: |
| Epilepsy is a common brain disease, and its pathogenesis is complex and unclear.With the development of electrophysiological technology, more and more research results reveal the connection between epilepsy and ion channels. Ion channels are key factors in the generation and regulation of excitability in the nervous system. As one of the subtypes of voltage-gated sodium channels (VGSCs), Nav1.6 mediates persistent Na+ current (INaP) and reactivated Na+ current (INaR), which is one of the important components of neuronal excitability. Changes in the expression of Nav1.6 channel and functional abnormalities caused by gene mutation play an important role in epilepsy. Further research on this channel will help to understand the pathogenesis of epilepsy and find effective treatments. |
| Key words: epilepsy pathogenesis NaV1.6 |
