雄激素受体在HER-2+（HR−），HER-2+（HR+）及三阴性乳腺癌中的表达及临床病理分析

breast cancer；androgen receptor；HER-2+(HR−)；HER-2+(HR+)；thriple negative breast cancer

关键词:  乳腺癌  雄激素受体  HER-2+(HR−)  HER-2+(HR−)  三阴性乳腺癌

Key words:  breast cancer  androgen receptor  HER-2+(HR−)  HER-2+(HR+)  thriple negative breast cancer

摘要:

目的 探讨雄激素受体（androgen receptor， AR）在HER-2+（HR?），HER-2+（HR+）及三阴性（triple-negative breast cancer， TNBC）乳腺癌中的表达及其与临床病理特征的关系。方法 收集2014年5月至2017年4月手术切除的260例HER-2+（HR+），HER-2+（HR?）和三阴性乳腺癌标本，采用免疫组织化学方法检测AR的表达情况，采用χ²检验分析AR在三个分型中的表达特点及其与临床病理特征的关系，采用Kaplan-Meier生存分析曲线显示AR在三个分型乳腺癌患者中的预后价值。结果 AR的表达与组织分级、组织学类型、组织是否存在坏死相关（P＜0.05），与ER、PR、HER-2、p53的表达有密切联系（P＜0.01）。AR在HER-2+（HR?），HER-2+（HR+）和三阴性乳腺癌中的表达率分别为85.71%（66/77），74.03%（57/77）和29.25%（31/106），三组间的差异具有统计学意义（P＜0.01）。生存曲线显示，AR阳性无病生存率高于AR阴性（P＜0.05），AR阳性和AR阴性总生存率差异无统计学意义。结论 AR的表达与HER-2+（HR?），HER-2+（HR+）及三阴性乳腺癌患者的组织分级、组织学类型、组织坏死以及预后等临床病理参数具有较好的相关性。

Abstract:

Objective To investigate the expression of androgen receptor (AR) in HER-2+(HR+), HER-2+(HR?) and triple　negative breast cancer and its relationship with clinicopathological parameters. Methods HER-2+(HR+), HER-2+(HR?) and　triple negative breast cancer 260 samples were collected from May 2014 to April 2017. The expression of AR in patients was　determined by immunohistochemistry. Chi-square test was used to analyze the expression characteristics of AR in the three　molecular types of breast cancer and its relationship with clinicopathological parameters. Kaplan-Meier survival analysis curve　was used to show prognosis of the three molecular types of breast cancer patients. Results The expression of AR was correlated　with histological type, histological grade and tumor necrosis (P＜0.05), as well as ER, PR, HER-2 and p53 expressions (P＜0.01).　The positive rates of AR in HER-2+(HR+), HER-2+(HR?) and triple negative breast cancer were 85.71% (66/77), 74.03% (57/77)　and 29.25% (31/106), respectively; and the differences among the three groups were statistically significant (P＜0.01). Meier　curves revealed that AR expression was related with disease free survival (P＜0.05). No significant relationship was found in　overall survival. Conclusion The expression of AR is correlated with the clinicopathological parameters such as histological type,　histological grade, tumor necrosis and the prognosis of HER-2+(HR+), HER-2+(HR?) and triple negative breast cancer patients.