| 摘要: |
| IgA肾病(immunoglobulin A nephropathy, IgAN)是一种常见的肾小球疾病，既往认为妊娠可能会加重IgAN进展。本文从妊娠期间血流动力学变化、妊娠期间体内激素、细胞因子变化以及IgAN发病过程中T细胞的作用等多种角度综述妊娠对IgAN的影响，同时结合目前的临床研究证明当满足一定条件时，妊娠并不会加重IgAN的进展。 |
| 关键词: IgA肾病 妊娠 雄激素 调节性T细胞 白细胞介素6 |
| DOI：10.11724/jdmu.2022.02.15 |
| 分类号:R692.3+1 |
| 基金项目: |
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| Effects of pregnancy on IgA nephropathy |
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FU Ya, SHENG Jie
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Department of Nephrology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
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| Abstract: |
| Immunoglobulin A nephropathy (IgAN) is A common glomerular disease. It was previously thought that pregnancy may aggravate the progression of IgAN. In this paper, from the perspectives of hemodynamic changes during pregnancy, changes of hormones and cytokines during pregnancy and the role of T cells in the pathogenesis of IgAN, we review the effects of pregnancy on IgAN. At the same time, combining with current clinical studies, we will demonstrate that pregnancy does not aggravate the progression of IgAN when certain conditions are met. |
| Key words: IgA nephropathy pregnancy androgens regulatory T cells interleukin 6 |
