血红素氧合酶-1在胃肠道疾病中的作用研究进展

Role of HO-1 in gastrointestinal diseases

关键词:  血红素氧合酶-1  炎症性肠病  消化道肿瘤  缺血/再灌注损伤

Key words:  hemeoxygenase-1  inflammatory bowel diseases  gastrointestinal tumor  ischemia/reperfusion injury

摘要:

血红素氧合酶-1（hemeoxygenase-1,HO-1）是血红素代谢过程中的限速酶，催化血红素裂解生成等分子的一氧化碳（carbon monoxide,CO）、胆绿素和Fe^2+。HO-1是一种公认的保护剂，具有抗炎、抗氧化的作用，并参与调控细胞增殖、凋亡、自噬等重要生命过程，对各种不同组织的创伤均具有保护作用。多项研究显示，HO-1在非甾体抗炎药（non-steroidal anti-inflammatory drugs,NSAIDs）相关性消化道损伤、炎症性肠病（inflammatory bowel disease,IBD）、肠缺血再灌注损伤、消化道肿瘤、胃瘫等多种消化道疾病中均有适应性表达，并起到保护胃肠组织和细胞的重要作用。本文就HO-1在消化道疾病防治中的作用及机制研究进行综述。

Abstract:

Hemeoxygenase-1 (HO-1) is a rate-limiting enzyme in heme metabolism, which cleaves heme into equimolar quantities of carbon monoxide (CO), biliverdin and Fe^2+.HO-1 is a recognized protective agent, which has anti-inflammatory and antioxidant effects and participates in the regulation of cell proliferation, apoptosis, autophagy and other important life processes, and plays a protective role in various tissue injuries. Multiple studies have shown that HO-1 plays an important role in protecting gastrointestinal tissues and cells and has adaptive expression in a variety of gastrointestinal diseases including non-steroidal anti-inflammatory drugs (NSAIDs) related gastrointestinal injury, inflammatory bowel disease disease(IBD),intestinal ischemia-reperfusion injury, gastrointestinal tumor, gastroparesis. We reviewed the role and mechanism of HO-1 in the prevention and treatment of gastrointestinal diseases.