| 引用本文: | 房佳霓,王雨婷,刘铭杰,乌尼热,孙仁凇,吕侠,唐泽耀,田燕,张建斌.超声触发药物递送系统用于癌症治疗的研究进展[J].大连医科大学学报,2021,43(6):533-540,548. |
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| 超声触发药物递送系统用于癌症治疗的研究进展 |
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房佳霓1, 王雨婷1, 刘铭杰1, 乌尼热1, 孙仁凇1, 吕侠2, 唐泽耀1, 田燕1, 张建斌1
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1.大连医科大学 药剂教研室, 辽宁 大连 116044;2.大连医科大学 方剂学教研室, 辽宁 大连 116044
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| 摘要: |
| 癌症是威胁人类健康的一大杀手，化疗为其常规治疗手段，但是化疗药由于毒副作用大、缺乏靶向性等问题导致疗效不佳。超声触发药物递送系统是一种新型的高效、无创的药物递送技术，其利用药物载体对超声波的响应，实现药物在肿瘤组织特异性释放，在癌症治疗方面具有重大的应用价值。本文就超声触发药物递送系统的作用机理、分类及其在癌症治疗方面的应用进行综述。 |
| 关键词: 超声 药物递送系统 癌症治疗 |
| DOI：10.11724/jdmu.2021.06.10 |
| 分类号:R944 |
| 基金项目:国家自然科学基金青年基金项目（81903560）；大连市青年科技之星项目（2018RQ81） |
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| Advances in ultrasound-triggered drug delivery system for cancer therapy |
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FANG Jiani1, WANG Yuting1, LIU Mingjie1, WUNIRE1, SUN Rensong1, LYU Xia2, TANG Zeyao1, TIAN Yan1, ZHANG Jianbin1
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1.Department of Pharmaceutics, Dalian Medical University, Dalian 116044, China;2.Department of Dosimetry, Dalian Medical University, Dalian 116044, China
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| Abstract: |
| Cancer is a major threat of human health. Chemotherapy is a conventional therapy of cancer, however, the efficacy of chemotherapy drugs is limited due to some problems such as toxic side effects and lack of targeting. Ultrasound-triggered drug delivery system (UTDDS) is a new, efficient and non-invasive technology for delivering drugs. As UTDDS is responsive to the ultrasound, it can achieve the specific release of chemotherapy drugs into tumor tissue by the stimulation of ultrasound. Hence, UTDDS shows great application value in cancer therapy. In this paper, the mechanism, types and applications of UTDDS in cancer therapy are reviewed. |
| Key words: ultrasound drug delivery system cancer therapy |