2型糖尿病脑病的多模态MRI成像

Multimodal MRI on diabetic encephalopathy in type 2 diabetes mellitus

关键词:  2型糖尿病  糖尿病脑病  MRI  功能成像

Key words:  type 2 diabetes mellitus  diabetic encephalopathy  MRI  functional imaging

摘要:

随着老龄化进程的加速，糖尿病（diabetes mellitus，DM）已成为继心脑血管疾病、恶性肿瘤之后，影响人类健康的第三大类慢性疾病。近年来，越来越多的研究发现2型糖尿病（type 2 diabetes mellitus，T2DM）可导致中枢神经系统改变，即糖尿病脑病（diabetic encephalopathy，DE）。T2DM患者进展为DE是一个隐匿性的慢性过程，早期临床症状常不典型，脑微结构、代谢、血流灌注及神经活动改变常常出现于脑部结构损害的早期阶段，甚至早于临床症状。基于多模态MRI技术，我们可以在体、定量评估T2DM的器质性脑损害，为临床评估疾病的发生、发展提供重要的影像学依据。

Abstract:

With the acceleration of the aging process, diabetes mellitus (DM) has become the third major chronic disease affecting human health after cardiovascular and cerebrovascular diseases and malignant tumors. In recent years, a growing number of studies have found that type 2 diabetes mellitus (T2DM) can lead to changes in the central nervous system, known as diabetic encephalopathy (DE). The progression of DE in T2DM patients is a latent and chronic process. The early clinical symptoms are often atypical. Changes in brain microstructure, metabolism, blood perfusion and neural activity often occur in the early stage of brain structural damage, even before the clinical symptoms. Based on multimodal MRI technology, we can quantitatively assess the organic brain damage of T2DM in vivo, providing an important imaging basis for the clinical evaluation of the occurrence and development of the disease.