终末期肾脏病患者的透析时机及其评价方法

Dialysis timing and its evaluation methods in ESRD patients

关键词:  透析时机  终末期肾脏病  临床结局  评价方法

Key words:  dialysis timing  ESRD  clinical outcome  evaluation methods

摘要:

透析时机是影响终末期肾脏病患者预后的独立危险因素，但目前关于终末期肾脏病患者的透析时机尚无定论。国内外研究以eGFR或Ccr界定早晚透析，但其与终末期肾脏病患者临床结局的关系结论不一。目前指南推荐的透析时机为eGFR或Ccr结合临床症状或体征。因诸多因素影响透析时机，所以需要进一步探索应用多因素评价透析时机的定量方法，开展更多随机对照研究以提供高质量的证据，为终末期肾脏病患者确定更适宜的透析时机。

Abstract:

Dialysis timing is an independent risk factor for ESRD patients. However, there is no consistent conclusion about dialysis timing. Studies have been using eGFR or Ccr to define early and late dialysis, but there are different conclusions on the relationship between dialysis timing and the clinical outcome for ESRD patients. Current guidelines suggest eGFR or Ccr combined with clinical symptoms or signs. Dialysis timing is affected by many factors. Therefore, it is necessary to further explore quantitative methods using multiple factors to evaluate dialysis timing and develop more randomized controlled trials to provide high-quality evidence to determine more appropriate dialysis timing for ESRD patients.