| 摘要: |
| 近年来的研究显示，炎症性肠病并发结直肠肿瘤的可能性增加，其发病机制尚未明确。遗传物质、炎症因子、信号通路以及肠道菌群等的一系列改变和相互作用被认为可能在炎症性肠病相关的癌变进程中发挥重要作用。本文从流行病学、危险因素、疾病发生机制等方面阐述炎症性肠病与肿瘤发生的相关性。 |
| 关键词: 炎症性肠病 肿瘤 机制 |
| DOI：10.11724/jdmu.2020.03.17 |
| 分类号:R735.3 |
| 基金项目: |
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| Mechanisms of colorectal cancer associated with inflammatory bowel disease |
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WANG Meiling1, ZHU Lei2, LIU Jiwei1
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1.Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;2.Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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| Abstract: |
| A number of studies have shown that inflammatory bowel disease is more likely to be complicated with colorectal cancer. However, the pathogenesis is not clear. A series of alterations and interactions of genetic material, inflammatory factors,signaling pathways, and intestinal flora are thought to play important roles in the carcinogenesis associated with inflammatory bowel disease. The correlation between inflammatory bowel disease and tumorigenesis will be elucidated on aspects of epidemiology, risk factors and pathogenesis of diseases in this literature review. |
| Key words: inflammatory bowel disease tumor mechanism |
