| 摘要: |
| 糖尿病是脑卒中的主要危险因素，糖尿病脑缺血的患者住院时间更长，长期残疾风险更高且预后不良。小胶质细胞是脑内驻留的巨噬细胞，脑损伤后会发生表型和功能改变，对脑组织有损害和修复作用。小胶质细胞/巨噬细胞表型转变在糖尿病合并缺血性脑损伤中发挥重要作用。本文针对小胶质细胞/巨噬细胞极化与糖尿病合并缺血性脑损伤的研究进展作一综述。 |
| 关键词: 小胶质细胞/巨噬细胞 极化 糖尿病脑缺血 |
| DOI：10.11724/jdmu.2020.03.15 |
| 分类号:R743 |
| 基金项目:遵市科合社字（2018）20号 |
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| Research progress of microglia/macrophage polarization in ischemic brain injury complicated with diabetes mellitus |
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AN Lulu, HAN Jiangquan, GUAN Jinfan, TIAN Mingqiao
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Department of Neurology, the Fifth Affiliated Hospital(Zhuhai) of Zunyi Medical University, Zhuhai 519100, China
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| Abstract: |
| Diabete mellitus is one of the most important risk factors for brain death. Patients with diabetic cerebral ischemia need longer hospitalization and are at higher risk for long-term disability and poor prognosis. Microglia are macrophages that reside in the brain. Phenotypes and functions of microglia can be altered during brain damage, causing damage and repair of brain tissue. The phenotype transformation of microglia/macrophage plays a dominant role in diabetic patients with ischemic brain injury. This article reviews the research progress of microglia/macrophage polarization in ischemic brain injury complicated with diabetes mellitus. |
| Key words: microglia/macrophage polarization diabetes cerebral ischemia |
