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| 长链非编码RNA IRAIN在肿瘤中的研究进展 |
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吕逸竹, 谢芳, 王海娜, 黄丹, 高贝贝, 闫金松
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大连医科大学附属第二医院 血液科, 大连市血液病重点实验室, 辽宁省造血干细胞移植医学中心, 辽宁省造血干细胞移植临床转化医学研究重点实验室, 辽宁 大连 116027
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| 摘要: |
| 长链非编码RNA（long noncoding RNAs，lncRNAs）是一种非编码RNA。随着新一代测序的应用，越来越多的lncRNAs被证实可以参与调控染色质重构、基因印迹、组蛋白修饰和DNA甲基化等多种生物学过程，同时参与肿瘤的发生发展。根据lncRNAs在恶性肿瘤中的作用，lncRNAs可以分为癌基因和肿瘤抑制基因。长链非编码RNA IRAIN是胰岛素样生长因子1受体（IGF1R）反义表达的印迹基因。在多种肿瘤，例如白血病、乳腺癌、非小细胞肺癌、胰腺癌、肝癌、喉癌和肾癌等中表达异常。本综述结合近期文献，总结IRAIN参与肿瘤的发生发展作用与分子机制，以期为肿瘤的诊断和治疗提供新的理论依据。 |
| 关键词: 长链非编码RNA IRAIN 肿瘤 |
| DOI：10.11724/jdmu.2020.01.14 |
| 分类号:R551.3 |
| 基金项目:国家自然科学基金面上项目（81570124）；国家自然科学基金青年基金项目（81702683）；辽宁省博士启动基金项目（20170520023）；大连市医学科学研究计划项目（1812036） |
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| Advances in research on long noncoding RNA IRAIN in different tumors |
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LYU Yizhu, XIE Fang, WANG Haina, HUANG Dan, GAO Beibei, YAN Jinsong
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Department of Hematology, the Second Affiliated Hospital of Dalian Medical University, Dalian Key Laboratory of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, Liaoning Key Laboratory of Hematopoietic Stem Cell Transplantation and Translational Medicine, Dalian 116027, China
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| Abstract: |
| Long noncoding RNAs (lncRNAs) are a type of noncoding RNA. With the extensive application of next generation sequencing, lncRNAs have been shown to be involved in the regulation of chromatin remodeling, gene imprinting, histone modification and DNA methylation, as well as the development of tumors. Based on the function of lncRNAs in tumors, lncRNAs can be classified into oncogenes and tumor suppressor genes. Long noncoding RNA IRAIN is an imprinted gene which transcribed from the antisense of insulin-like growth factor 1 receptor (IGF1R). Abnormal expression of IRAIN has been discovered in a variety of tumors, such as leukemia, breast cancer, non-small cell lung cancer, pancreatic cancer, liver cancer, laryngeal cancer and kidney cancer. This review summarizes the role and molecular mechanisms of IRAIN involved in tumor development. |
| Key words: long noncoding RNA IRAIN tumor |