摘要: |
目的 分析肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)的流行病学及临床特征,为HFRS的早期临床诊断提供参考依据。方法 回顾性分析大连医科大学附属第二医院2005年1月至2018年3月收治的实验室确诊为HFRS的患者74例,其中男48例,女26例,年龄14~86岁,分析其临床症状和体征、实验室检查、误诊情况、治疗费用和转归情况,应用SPSS 25.0对数据进行统计分析。结果 临床症状中发热症状最多见,占93.24%,其次为乏力、头痛、腰痛、恶心、呕吐、少尿或无尿,具有典型"三红三痛"临床表现病例仅21例,占28.37%。临床分型以轻型和中型居多。实验室检查以肾功能损伤、急性血小板减少、肝功能损伤为主。首诊误诊病例共19例,误诊率25.7%。结论 HFRS具有典型临床表现者少,误诊率高。临床医生需加强对该病的认识。 |
关键词: 肾综合征出血热 流行病学 临床特征 |
DOI:10.11724/jdmu.2019.06.09 |
分类号:R512.8 |
基金项目: |
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Epidemiological and clinical characteristics of hemorrhagic fever with renal syndrome |
GAO Junlan, YU Jian, WANG Zhiyu, ZHUANG Chengjun
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ICU, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
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Abstract: |
Objective To study the epidemiological characteristics, clinical features, laboratory tests and misdiagnosis of hemorrhagic fever with renal syndrome (HFRS),in order to provide guidance for prevention and clinical diagnosis of HFRS. Methods A total of 74 clinical cases, which were diagnosed as HFRS by laboratory examinations in the Second Hospital of Dalian Medical University from January 2005 to March 2018, were collected including 48 men and 26 women, aged 14-86 years. The clinical manifestations, laboratory tests, misdiagnosis, treatment costs and prognosis were observed. Statistical analysis was performed retrospectively using SPSS 25.0. Results Fever was the most common clinical symptom accounting for 93.24%, followed by fatigue, headache, back pain, nausea vomiting, oliguria or anuria, with typical "three red three pain" clinical manifestations in only 21cases (28.37%). Clinical manifestations were mostly light and medium. Laboratory tests were mainly characterized by renal impairment, acute thrombocytopenia, and liver function impairment. A total of 19 cases were misdiagnosed with a misdiagnosis rate of 25.7%. Conclusions HFRS has few typical clinical manifestations and high misdiagnosis rate. Clinicians need to strengthen the understanding of the disease. |
Key words: hemorrhagic fever with renal syndrome epidemiology clinical features |