中药治疗帕金森病作用机制研究进展

Advance in mechanisms of Traditional Chinese Medicine treating Parkinson's disease

关键词:  帕金森疾病  中药  作用机制

Key words:  Parkinson's disease  Traditional Chinese Medicine  mechanism

摘要:

帕金森疾病(Parkinson's disease，PD)是一种发病率居第二位的重大神经系统退行性疾病，严重影响患者生活质量。目前，中医药在治疗PD方面，已经取得显著疗效，且不良反应较轻。中药可通过抗氧化应激、抑制细胞凋亡、减轻神经免疫炎症反应、抑制蛋白异常聚集、诱导自噬、改善线粒体能量代谢等方面发挥延缓或治疗PD的作用。

Abstract:

Parkinson's disease (PD) is the second most common neurodegenerative disease, which greatly decreases the life quality of patients. Traditional Chinese Medicine displays potent clinical efficacy for the treatment of PD, which avoids multiple adverse effects of western medicine. However, the systemic summary for the potential mechanisms is still lacking. In this review article, the underlying mechanisms of Traditional Chinese Medicine to treat PD were summarized from the following six aspects: anti-oxidative stress, anti-apoptosis, anti-neuroinflammation, anti-protein abnormal aggregation, autophagy activation and improvement of mitochondrial energy metabolism, which may provide novel directions for the treatment of this neurodegenerative disorder in future.