血清CXCL12浓度与颈动脉粥样硬化的相关性研究

Correlation between serum CXCL12 concentration and carotid atherosclerosis

关键词:  CXCL12  动脉粥样硬化  颈动脉  趋化因子

Key words:  CXCL12  atherosclerosis  carotid  chemokine

摘要:

目的　探讨血清CXCL12浓度在颈动脉粥样硬化评估中的价值。方法　对2015年4月至2017年11月在大连市友谊医院就诊的113例患者（68例男性，45例女性），采用ELISA方法检测血清中CXCL12浓度。根据颈部血管超声学检查结果，按照颈动脉内-中膜厚度（intima-median thickness, IMT）和斑块情况进行不同的分组，对颈动脉粥样硬化的相关危险因素进行分析。结果　血清CXCL12浓度与IMT增厚和不稳定斑块密切相关，IMT增厚组 （IMT＞1.0 mm）血清CXCL12浓度水平显著低于正常IMT组（IMT≤1.0 mm），差异均有统计学意义(P<0.05)；不稳定斑块组血清CXCL12浓度水平低于稳定斑块组和无斑块组，与两组相比，差异有统计学意义(P<0.05)。Logistic回归结果显示，低血清CXCL12浓度是IMT及斑块稳定性的独立危险因素（P=0.028, P=0.031）。结论　血清CXCL12可能会成为发现、预防和评估由动脉粥样硬化引起的心脑血管疾病的具有临床应用价值的一种生物学标志物。

Abstract:

Objective To investigate the value of serum CXCL12 concentration in the evaluation of carotid atherosclerosis. Methods Serum concentrations of CXCL12 was detected by ELISA in 113 patients (68 males and 45 females) from April 2015 to November 2017. Different groups were divided according to intima-median thickness (IMT) and plaque status by the ultrasonographic findings of carotid artery, and the risk factors of carotid atherosclerosis were analyzed according to the intima-median thickness (IMT) and plaque status by intergroup comparison and correlation statistics. Results Serum CXCL12 concentration was closely related to IMT thickening and unstable plaques. Serum CXCL12 level in IMT thickening group (IMT＞1.0 mm) was significantly lower than that in normal IMT group (IMT≤1.0mm), and the difference was statistically significant (P<0.05). Serum CXCL12 level in unstable plaque group was lower than those in stable plaque group and without plaque group, and the difference was statistically significant (P<0.05). Logistic regression analysis revealed that serum CXCL12 concentration was an independent risk factor for carotid atherosclerosis (P=0.028, P=0.031). Conclusion Serum CXCL12 may be a clinically valuable biomarker for the detection, prevention, and evaluation of cardiovascular and cerebrovascular diseases caused by atherosclerosis.