| 摘要: |
| 视网膜色素变性（RP）是一组遗传性视网膜疾病，其特征是视杆细胞变性，进而视锥细胞受累，所有感光细胞变性，致严重的视觉功能障碍，最终双眼失明。本文在简述RP概况的基础上，重点评述RP的基因检测及相关新型治疗策略，包括基因治疗、细胞移植和视网膜假体，为后续视网膜色素变性相关的诊断、治疗和研究提供依据。视网膜色素变性；基因检测；基因治疗；细胞移植；视网膜假体 |
| 关键词: 视网膜色素变性 基因检测 基因治疗 细胞移植 视网膜假体 |
| DOI：10.11724/jdmu.2018.02.01 |
| 分类号: |
| 基金项目:基金项目：国家自然科学基金项目（81770970，81271022）；国家科技部重大专项子课题（2017YFA0105300） |
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| New strategies for diagnosis and treatment of retinitis pigmentos |
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MA Xiang
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Department of Ophthalmology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
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| Abstract: |
| Retinitis pigmentosa (RP) is a group of inherited retinal diseases which is characterized by the degeneration of the rods in the beginning, and then the cones. Eventually, all of the photoreceptor cells are involved, accompanied by severe visual dysfunction and ultimately blindness of both eyes. Based on a brief overview of the RP profile, this article focuses on genetic test and related novel therapeutic strategies of RP, including gene therapy, cell transplantation, and retinal prosthesis, in order to provide a basis for future related research, diagnosis and treatment. |
| Key words: retinitis pigmentosa genetic test gene therapy cell transplantation retinal prosthesis |
