玻璃体蛋白质组学在眼部疾病研究中的应用

Application of vitreous proteomic in the research of ocular disease

关键词:  玻璃体  蛋白质组学:糖尿病性视网膜病变  糖尿病性黄斑水肿  增生性糖尿病视网膜病变  年龄相关性黄斑变性

Key words:  vitreous body  proteomics  diabetic retinopathy  diabetic macular edema  proliferative diabetic retinopathy  age-related macular degeneration

摘要:

玻璃体中存在可影响视网膜生理学的多种蛋白质，包括生长因子、激素、具有转运蛋白活性的蛋白质和酶等。在许多疾病状态下玻璃体的蛋白质组成会有所改变，蛋白质组学方法可检测用于眼部疾病或蛋白质波动的特定的生物学标志物，其内容包括鉴定蛋白质的表达、存在方式（修饰形式）、 结构、功能和相互作用等，揭示眼部疾病机制并为药物治疗提供依据。本文对玻璃体蛋白质组学在眼部疾病研究中的应用作一综述。

Abstract:

In vitreous humor, a diversity of proteins that can influence retinal physiology are present, including growth factors, hormones, proteins with transporter activity, and enzymes. The protein composition of vitreous humor has been described as being altered in a number of diseases. Therefore, detecting putative biomarkers for ocular illness or protein fluctuations with possible physiologic significance have been conducted, using proteomic approaches. This includes the identification of protein expression, presence (modification), structure, function and interaction, reveals the mechanism of ocular disease, and provides a basis for drug treatment. This article will review the application of vitreous proteomics in the study of ocular diseases.