2型糖尿病患者的早期胰岛素强化治疗

Early intensive insulin therapy in patients with type 2 diabetes

关键词:  2型糖尿病  早期胰岛素强化治疗  胰岛B细胞  胰岛素抵抗

Key words:  type 2 diabetes  early intensive insulin therapy  islet B cell  vascular complication

摘要:

2型糖尿病是以逐渐损伤的胰岛B细胞功能和胰岛素抵抗为主要特征的代谢疾病。早期胰岛素强化治疗作为一种治疗2型糖尿病人的新型疗法，能严格控制病人血糖，有效改善胰岛B细胞功能和胰岛素抵抗，使得患者在一定时间内仅靠饮食运动就可以保持正常血糖，但也存在着低血糖和体重增加等副作用。本文就早期胰岛素强化治疗的概念、方案、作用以及可能存在的问题进行综述。

Abstract:

Type 2 diabetes is a metabolic disease characterized by the progressive deterioration of islet B cell function and insulin resistance. Early intensive insulin therapy, as a novel strategy of type 2 diabetes, can improve islet B cell function and insulin resistance by achieving restrictive glycemic control using insulin. This therapy enables patients to maintain normal blood glucose level after the therapy merely on lifestyle interventions and diet control. However, early intensive insulin therapy may cause some side effects, including increased risk of hypoglycemia and weight gain. This article reviews the definition, the therapeutic schemes, the effects and possible problems of early intensive insulin therapy. We hope that we can help physicians and medical students learn more about this therapy.