醒脑静注射液对外伤性颅脑损伤疗效的研究

Clinical effect of Xingnaojing injection in traumatic brain injury

关键词:  醒脑静注射液  外伤性颅脑损伤  脑挫裂伤  血清离子

Key words:  Xingnaojing injection  traumatic brain injury  cerebral contusion  serum ion

摘要:

目的　探讨醒脑静注射液对外伤性颅脑损伤疗效的研究。方法　选取北京朝阳中西医结合出诊抢救中心2013年12月至2015年7月收治符合纳入标准的外伤性颅脑损伤患者72例。其中对照组36例，予以营养脑细胞、脑保护治疗及早期功能康复训练；研究组36例，在对照组治疗方案基础上予以醒脑静注射液治疗，共治疗14 d。比较治疗前后GCS、MoCA、NIHSS评分及治疗后GOS评分，治疗前后采血测定炎症介质，神经损伤蛋白及离子水平，对比临床疗效及不良反应。结果　与治疗前比较，两组治疗后GCS、MoCA评分升高，NIHSS评分降低（P＜0.05）；与对照组比较，研究组治疗后GCS、GOS、MoCA评分较高，NIHSS评分较低（P＜0.05）。与治疗前比较，两组治疗后血清hs-CRP、TNF-α、IL-6以及IL-18含量降低（P＜0.05）；与对照组比较，研究组治疗后血清hs-CRP、TNF-α、IL-6以及IL-18含量较低（P＜0.05）。与治疗前比较，两组治疗后血清GFAP、MBP、NSE以及S100β含量降低（P＜0.05）；与对照组比较，研究组治疗后血清GFAP、MBP、NSE以及S100β含量较低（P＜0.05）。与治疗前比较，两组治疗后血清Ca2+、Zn2+以及Mg2+含量升高（P＜0.05）；与对照组比较，研究组治疗后血清Ca2+、Zn2+以及Mg2+含量较高（P＜0.05）。对照组有效率69.44%，与研究组有效率88.89%对比，差异有统计学意义（P＜0.05）。对照组不良反应发生率13.89%，研究组不良反应发生率16.67%，两组间无明显差异（P＞0.05）。结论　醒脑静注射液对外伤性颅脑损伤具有良好疗效，可降低神经损伤及炎症指标，提高离子水平，值得推广。

Abstract:

Objective To study the clinical effect of Xingnaojing Injection in traumatic brain injury. Methods Seventy-two patients with traumatic head injury admitted from December 2013 to July 2015 were randomly divided into control group and study group (n=36). The control group received nourishment Brain cells and brain protection, the study group received Xingnaojing Injection in addition to nutrition brain cells and brain protection. Both groups were treated for 14 days. Blood samples were taken for the measurement of levels of inflammatory mediators, nerve injury and ion, levels of GCS, GOS, MoCA and NIHSS scores. The clinical efficacy and adverse reactions were compared. Results Compared to those before treatment, serum levels of GCS, MoCA, NIHSS, hs-CRP, TNF-α, IL-6 and IL-18 in the two groups significantly decreased, levels of GFAP, MBP, NSE and S100β decreased , and levels of Ca2+, Zn2+ and Mg2+ in serum increased (P<0.05). Compared to the control group, the scores of GCS, GOS and MoCA in the study group were higher, the NIHSS score was lower, the serum levels of hs-CRP, TNF-α, IL-6 and IL-18 were lower, levels of GFAP, MBP, NSE and levels of Ca2+, Zn2+ and Mg2+ in serum were higher (P<0.05). The effective rate in the control group (69.44%) was lower than the study group (88.89%), P<0.05. There was no significant difference between the two groups (P>0.05). Conclusion Xingnaojing injection is effective for traumatic brain injury, reducing the nerve injury and inflammation index and improving the ion level, and is worth popularized.