| 摘要: |
| 心肌纤维化是指正常的心肌组织结构中胶原纤维的过量沉积,其胶原浓度和胶原容积分数显著增加、各型胶原比率失调及排列紊乱。这种病理变化是心脏重构的重要体现，是多种心血管病发展的终末阶段。赖氨酸氧化酶（lysyl oxidase，LOX）负责胶原蛋白I型与III型的相互交联，促进胶原纤维的沉积，决定着细胞外间质的稳定。LOX是心肌纤维化过程的关键因子。本文就LOX与心肌纤维化的关系及机制进行综述。 |
| 关键词: 赖氨酸氧化酶 心肌纤维化 盘状结构域受体酪氨酸激酶 转化生长因子β |
| DOI：10.11724/jdmu.2017.02.19 |
| 分类号:R541 |
| 基金项目: |
|
| Research progress on the relationship between lysine oxidase and myocardial fibrosis |
|
ZHAO Lei 11, ZHANG Shuying2, LIU Hui3
|
|
1.Zunyi Medical College, Zunyi 563000, China;2.Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116000，China;3.Department of Cardiology, Guizhou Provincial People's Hospital, Guiyang 550002, China
|
| Abstract: |
| Myocardial fibrosis is the excessive deposition of collagen fibers in the normal tissue structure of the myocardium. Consequently, the collagen concentration and the collagen volume fraction increase significantly, and the ratio of collagen is disordered. This pathological change is an important manifestation of cardiac remodeling and the end stage in the development of a variety of cardiovascular diseases. Lysyl oxidase (LOX), which is responsible for the cross-linking of type I and type III collagen, promotes the deposition of collagen fibers and determines the stability of the extracellular matrix. LOX is a key factor in myocardial fibrosis, and the relationship between LOX and myocardial fibrosis is reviewed in this paper. |
| Key words: lysyl oxidase myocardial fibrosis DDRs transform growth factor β |
