| 摘要: |
| 急性心肌梗死后的左室重塑是导致心力衰竭重要的病理生理过程，也是导致心脏性死亡的重要危险因素。基质金属蛋白酶（MMPs）与基质金属蛋白酶组织抑制因子（TIMPs）是维持细胞外基质（ECM）平衡的调控物质。心梗后的左室重塑与组织基质金属蛋白酶系统失衡导致的ECM降解有密切关联。本文对MMPs/TIMPs系统在心梗后心室重塑中的调节机制及其作用作一综述。 |
| 关键词: 基质金属蛋白酶 基质金属蛋白酶组织抑制因子 信号通路 心肌梗死 心室重塑 |
| DOI：10.11724/jdmu.2016.04.23 |
| 分类号:R541.7+8，R542.2+2 |
| 基金项目: |
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| Ventricular remodeling after myocardial infarction and tissue matrix metalloproteinase system |
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ZHENG Xi, ZHU Peng-li, YU Hui-zhen
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Internal Medicine, Provincial Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Geriatric Medicine Research Institution of Fujian Provincial Hospital, JinShan Branch Courts of Fujian Provincial Hospital, Fuzhou 350001, China
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| Abstract: |
| It is well known that left ventricular remodeling after acute myocardial infarction is an important pathophysiological process in the process of heart failure, and it is also an important risk factor for cardiac death. Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) are regulators of extracellular matrix (ECM) balance. The left ventricular remodeling after myocardial infarction is closely related to the imbalance of the tissue matrix metalloproteinase system, which leads to the ECM degradation. In this paper, the regulation mechanism and function of MMPs/TIMPs system in ventricular remodeling after myocardial infarction are reviewed. |
| Key words: matrix metalloproteinases tissue inhibitor of matrix metalloproteinases signaling pathway myocardial infarction ventricular remodeling |
