微生态制剂辅助治疗婴幼儿湿疹的临床效果研究

Clinical effect of microecologics as an adjuvant therapy on infants’ eczema

关键词:  湿疹  益生菌  免疫  婴幼儿

Key words:  eczema  probiotics  immune  infant

摘要:

目的　观察微生态制剂辅助治疗婴幼儿湿疹的临床疗效。　方法　180例湿疹患儿随机分为两组，对照组和试验组，每组90人。对照组采用常规对症治疗，试验组在常规对症治疗的基础上同时给予微生态制剂双歧杆菌四联活菌片，每次1片，2次/d口服，疗程为1个月，进行辅助治疗。疗程结束分析两种治疗方案的有效率，评价两种方案的疗效。应用酶联免疫反应法检测两组患儿治疗前后血液白介素（IL）-4，IL-10，干扰素（IFN）-γ及免疫球蛋白E(IgE)含量，流式细胞术分析T细胞亚型Th1/Th2比例。　结果　试验组有效率91.1%，与对照组76.7%比较，差异有显著性意义，P<0.05；同时血液IL-4，IL-10及IgE较治疗前降低，IFN-γ及Th1/Th2比例较治疗前升高，差异均具有显著性意义（P<0.05）。3个月后，湿疹复发情况的随诊结果显示，试验组复发率为26.7%，对照组复发率为68.9%，二者相比差异明显（P<0.05）。　结论　　应用微生态制剂辅助治疗婴幼儿湿疹可以明显增加治疗的有效率，增强宿主的免疫自稳功能，减少复发率，值得推广应用。

Abstract:

Objective To study the clinical effect of microecologics on infants′ eczema. Methods Totally 180 eczema patients were randomly divided into two groups: the control group and the experimental group with 90 patients in each group. Patients in the control group were treated with routine symptomatic treatment and patients in the experimental group were treated with routine symptomatic treatment plus combination of four living bacterium tablet. The microecologics were taken orally, one tablet a time and twice a day for one month. The effective rate of the two therapeutic methods was analyzed and the levels of IL-4, IL-10, IgE, IFN-γ and Th1/Th2 ratio in blood were examined. The relapse rate of the two groups in the three months follow up visit was analyzed. Results Effective rate in the experimental group was 91.1%, much higher than the control group with statistical significance (P<0.05). Levels of IL-4, IL-10 and IgE in blood serum decreased significantly in the experimental group when compared to the control group (P<0.05) and level of IFN-γ and Th1/Th2 ratio increased significantly in the experimental group when compared to the control (P<0.05). The 3 months eczema relapse rate was 26.7% in the experimental group and 68.9% in the control group. The difference between the two groups was statistically significant. Conclusion Applying microecologics as an adjuvant therapy for eczema treatment could increase the effective rate and decrease the 3 months relapse rate, meanwhile enhance the self-stabilization of immune system. Microecologics has very wide popularization and application prospects for eczema treatment.