哮喘患儿血清VEGF、IL-13的表达水平及临床意义

Clinical significance of serum VEGF and IL-13 levels in asthmatic children

关键词:  哮喘  VEGF  IL-13  儿童

Key words:  [Key words]　asthma  VEGF  IL-13  children

摘要:

[摘要]　目的　研究哮喘患儿血清VEGF、IL-13的表达水平，探讨VEGF、IL-13在儿童哮喘发病机制中的作用。　方法　随机选取哮喘急性发作期患儿34例（发作期组），哮喘临床缓解患儿30例（缓解期组），正常健康体检儿童26例（对照组）。采用ELISA方法检测3组儿童血清VEGF、IL-13的水平。　结果　发作期组患儿血清VEGF表达水平(383.42±25.78)pg/mL明显高于缓解期组(177.95±22.46)pg/mL和对照组(70.56±18.94) pg/mL，差异有显著性意义（P<0.01）；缓解期组患儿血清VEGF表达水平与对照组比较，差异也具有显著性意义（P<0.01）。发作期组患儿血清IL-13表达水平(56.13±9.96)pg/mL明显高于缓解期组(36.72±6.29)pg/mL和对照组(20.21±2.36)pg/mL，差异有显著性意义（P<0.01）；缓解期患儿血清IL-13表达水平与对照组比较，差异也具有显著性意义（P<0.01）。　结论　血清VEGF、IL-13表达水平升高在儿童哮喘的发病机制中起重要作用，且可反映哮喘的严重程度。

Abstract:

[Abstract]　Objective　To study serum VEGF and IL-13 levels in asthmatic children and explore the role of VEGF and IL-13 in pathogenesis of the disease.　Methods　Patients were randomly selected including 34 asthmatic children with acute exacerbation (acute exacerbation group), 30 asthmatic children with clinical remission (clinical remission group), and 26 healthy children (control group). Serum VEGF and IL-13 levels were measured by enzyme-linked immuno sorbent assay (ELISA).　Results　The levels of serum VEGF in acute exacerbation group (383.42±25.78)pg/mL were significantly higher than those in clinical remission group (177.95±22.46)pg/mL and control group (70.56±18.94)pg/mL (P<0.01). The levels of serum VEGF in clinical remission group were significantly higher than those in control group (P<0.01). The levels of serum IL-13 in acute exacerbation group (56.13±9.96)pg/mL were significantly higher than those in clinical remission group (36.72±6.29)pg/mL and control group (20.21±2.36)pg/mL (P<0.01). The levels of serum IL-13 in clinical remission group were significantly higher than those in control group (P<0.01).　Conclusion　Elevated serum VEGF and IL-13 may play important roles in the pathogenesis of asthma and can reflect disease severity in asthmatic children.