| 摘要: |
| [摘要] Bcl-2家族蛋白是细胞凋亡的关键调节分子，线粒体、内质网等在细胞凋亡的过程中扮演着重要的角色，Bcl-2家族蛋白可直接或间接作用于线粒体来发挥它们的相应功能。Bcl-2基因家族在缺血再灌注损伤(IRI)中也有着独特的地位。而且Bcl-2家族的表达和调控对肿瘤细胞凋亡也具有较大的影响，如何调控Bcl-2家族成员的表达和表达后的针对性治疗，成为今后研究的一个方向。本文对Bcl-2目前的研究进展作一综述。 |
| 关键词: Bcl-2 细胞凋亡 线粒体 内质网 缺血再灌注损伤 |
| DOI：10.11724/jdmu.2015.02.25 |
| 分类号: |
| 基金项目: |
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| Research progress of the Bcl-2 gene family |
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REN Yu-wei,SU Hua-wei
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Department of Biliary,Laparoscopic Minimally Invasive Surgery,the Second Affiliated Clinical Hospital of Harbin Medical University,Harbin 150086，China
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| Abstract: |
| [Abstract] Bcl-2 family proteins are key regulatory molecules of apoptosis. Mitochondria and endoplasmic reticulum etc. play important roles in the process of apoptosis. Bcl-2 family proteins can have direct or indirect effects on mitochondria to play its function. Bcl-2 gene family has also a unique role in ischemia-reperfusion injury (IRI). The expression and regulation of Bcl-2 family has great influence on tumor cell apoptosis. How to regulate the expression of Bcl-2 family members and the expression-related target therapy have become a direction of future research. This article summarizes the present research progress. |
| Key words: [Key words] Bcl 2 cell apoptosis mitochondria endoplasmic reticulum (ER) ischemia reperfusion injury（IRI） |
