| 摘要: |
| [摘要] 甲状腺癌来源于甲状腺滤泡上皮细胞，是最常见的甲状腺恶性肿瘤，约占全身恶性肿瘤的1.3%~1.5%，且近年来有增长趋势。p53基因的突变、缺失、重组和失活在人类许多肿瘤的形成和发展过程中起重要作用。泛素连接酶Pirh2是一种具有E3连接酶活性的新蛋白，能促进p53发生泛素化而降解，从而使p53抑制肿瘤生长的功能减弱或消失，导致肿瘤发生和进一步恶化。随着对肿瘤基因的深入研究，找到与甲状腺癌发生、发展、转归相关的癌基因，为肿瘤的诊治提供临床依据，成为目前研究热点。本文就Pirh2与p53在甲状腺癌中研究进展进行综述。 |
| 关键词: 甲状腺癌 Pirh2 p53 |
| DOI：10.11724/jdmu.2015.02.23 |
| 分类号: |
| 基金项目:基金项目：湖南省长沙市科学技术局项目（K1303034-31） |
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| Research progress of Pirh2 and p53 in thyroid carcinoma |
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XIONG Fang 1,FAN Pei-zhi 2,ZHANG Chao-jie 21,2
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1.Department of Surgery,the First Affiliated Hospital of Hunan Normal University,Changsha 410005,China;2.Department of Breast and Thyroid Surgery,Hunan Province People's Hospital,Changsha 410005,China
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| Abstract: |
| [Abstract] Thyroid carcinoma is the most common malignant tumor of thyroid,derived from thyroid follicular epithelial cells. It represents approximately 1.3%-1.5% of all malignant tumors and the incidence is increasing in recent years. Mutation,deletion and recombinant p53 gene inactivation play important roles in the process of formation and development of many human tumors. Ubiquitin ligase Pirh2 is a new protein with E3 ligase activity. It promotes p53 ubiquitination and subsequent degradation,and thus inhibit the anti-tumor function of p53,resulting in tumor formation and deterioration. With progression in cancer research,identification of novel genes related to the occurrence,development and prognosis of thyroid cancer has become a hot research spot. This review summarizes research progress of Pirh2 and p53 in thyroid carcinoma. |
| Key words: [Key words] thyroid cancer Pirh2 p53 |
