EGFR和K-ras蛋白在大肠息肉中的表达及临床意义

Expressions and clinical significance of EGFR and K-ras protein in colorectal polyps

关键词:  大肠息肉  EGFR  K-ras

Key words:  [Key words]　colorectal polyps  EGFR  K-ras

摘要:

[摘要]　目的　探讨EGFR及K-ras蛋白在大肠息肉中的表达及临床意义。　方法　免疫组化法检测大肠息肉及大肠癌组织EGFR和K-ras的蛋白表达。总结大肠息肉组中EGFR和K-ras蛋白表达与临床参数的关系，并分析两种蛋白表达的相关性。　结果　大肠腺瘤性息肉及大肠癌组的EGFR蛋白阳性表达率分别为64.29%与62.61%，均高于大肠非腺瘤性息肉组的32.00% (P<0.05)；大肠腺瘤性息肉组的K-ras蛋白阳性表达率为78.57%，高于大肠非腺瘤性息肉及大肠癌组的36.00%及46.09%(P<0.05)。两种蛋白表达在组织学分型方面比较有差异(P<0.05)，而在性别、年龄、息肉数量及部位方面比较无差异。在大肠息肉中EGFR与K-ras蛋白表达呈显著正相关(r=0.444，P<0.005)。　结论　EGFR及K-ras蛋白在大肠腺瘤性息肉中有一定表达；二者的表达升高可能与大肠腺瘤性息肉的发生与恶性转化有一定关系；二者在大肠息肉的发生发展中有协同作用。

Abstract:

[Abstract] Objective　To explore the expressions and significance of EGFR and K〖KG-*2〗-ras protein in colorectal polyps.　Methods　EGFR and K-ras protein expressions in colorectal polyps and colorectal cancer were detected by immunohistochemistry.　Results　The positive expression rates of EGFR in colorectal adenomatous polyp group and colorectal cancer group were 64.29% and 62.61% respectively. They were higher than that at colorectal non-adenomatous polyp group Both of them being 32.00% (P<0.05); The positive expression rate of K-ras in colorectal adenomatous polyp group was 78.57%. It was higher than those of colorectal non-adenomatous polyp group 36.00% and colorectal cancer group 46.09%(P<0.05). EGFR and K-ras protein expressions existed statistic difference in colorectal polyp histopathology (P<0.05), but there were no statistic significance in sex, age, number and site of colorectal polyp. The expressions of these two proteins in colorectal polyp group showed a significant positive correlation (r=0.444，P<0.005).　Conclusion　A certain level of expression of EGFR and K-ras protein exists in the colorectal adenomatous polyps. The increased expression of the two proteins may be related to the occurance and malignant transformation of colorectal adenomatous polyps; The two proteins play a synergistic role in the occurrence and progrusssim of colorectal polyps.