| 摘要: |
| [摘要] 目的 探讨原发性高血压患者同型半胱氨酸（Hcy）血症对血压变异性及左心室肥厚的影响。 方法 入选高血压患者148例，根据Hcy水平，分为H型高血压组（H组，Hcy≥15 mmol/L）及非H型高血压组（非H组，Hcy<15 mmol/L），两组均查动态血压，记录血压变异性；彩色多普勒超声测定左心室形态结构，并计算左心室质量及左心室质量指数。比较两组患者血压变异性及左心室肥厚指标。 结果 H组患者24 h收缩压、舒张压变异率、日间收缩压、舒张压变异率、夜间收缩压、舒张压变异率均高于非H组[分别为（16.4±6.6）vs（13.6±7.3）、（10.3±5.8）vs.（9.7±5.4）、（15.7±5.6）vs.（12.6±4.9）、（9.6±3.7）vs.（8.8±3.2）、（12.4±4.8）vs.（11.5±3.8）、（9.1±3.3）vs.（8.4±2.7）mmHg]，差异均有显著性意义，P<0.05；H组患者室间隔厚度、 左室后壁厚度、 舒张末期左室内径、收缩末期左室内径、左心室质量、左心室质量指数均高于非H组[分别为（11.3±1.4）vs.（10.5±1.5）、（11.5±1.3）vs.（10.1±1.3）、（47.5±3.3）vs.（46.4±4.0）、（27.1±3.8）vs.（26.5±3.4）mm，（190.7±30.2）vs.（174.5±33.8）g，（105.1±9.8）vs.（93.6±11.5）g/m2]，P<0.05。 结论 高Hcy血症是高血压患者血压变异性增高及左心室肥厚的危险因素。 |
| 关键词: [关键词] 原发性高血压 同型半胱氨酸 血压变异性 左心室肥厚 |
| DOI：10.11724/jdmu.2014.04.09 |
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| 基金项目: |
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| Effect of serum homocysteine on blood pressure variability and left ventricular hypertrophy in essential hypertension |
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LIU Kun 1, ZHANG Ying 2, TANG Qiang 11,2
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1.Cardiovascular Department，Beijing University Shougang Hospital，Beijing 100041，China;2.Cardiovascular Department，the First Affiliated Hospital of Dalian Medical University，Dalian 116011，China
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| Abstract: |
| [Abstract] Objective To observe the effect of serum homocysteine on blood pressure variability and left ventricular hypertrophy in patients with essential hypertension. Methods 148 patients with essential hypertension were divided into two groups based on serum homocysteine (Hcy) level. The blood pressure variability and left ventricular hypertrophy were measured and compared in the two groups. Results Levels of 24h SSD，24h DSD，dSSD，dDSD，nSSD，and nDSD in the High-Hcy group were higher than those in the control group (P<0.05). They were（16.4±6.6）vs.（13.6±7.3），（10.3±5.8）vs.（9.7±5.4）、（15.7±5.6）vs.（12.6±4.9），（9.6±3.7）vs.（8.8±3.2），（12.4±4.8）vs.（11.5±3.8），and（9.1±3.3）vs.（8.4±2.7）mmHg，respectively. Levels of IVST，LVPWT，LVEDD，LVESD，LVM，and LVMIH in the High-Hcy group were higher than those in the control group (P<0.05). They were（11.3±1.4）vs.（10.5±1.5），（11.5±1.3）vs.（10.1±1.3），（47.5±3.3）vs.（46.4±4.0），（27.1±3.8）vs.（26.5±3.4）mm，（190.7±30.2）vs.（174.5±33.8）g，and（105.1±9.8）vs.（93.6±11.5）g/m 2，respectively. Conclusion Hyperhomocystinemia is a risk factor of blood pressure variability and left ventricular hypertrophy in essential hypertension patients. |
| Key words: [Key words] essential hypertension homocysteine blood pressure variability left ventricular hypertrophy |
